Anti-VEGF antibody is a Chimeric antibody (mouse/human) of IgG1 κ class that binds to an VEGF.
Figure 1 The effects of VEGF Trap, ranibizumab and bevacizumab on calcium mobilization induced byVEGF-A165 in HUVEC.
Serial dilutions of VEGF Trap (open box), ranibizumab (triangle) or bevacizumab (closed circle) were added to HUVEC along with 20 pM of VEGF-A165. The VEGF-A165 was preincubated with the inhibitors for 10 min at 25 C. The solution was added to HUVEC preloaded with fluo-4 and the fluorescence of the well was determined on a FLIPR instrument. The data were plotted using a four parameter curve fit with GraphPad Prism. Each point represents duplicate wells at each concentration.
Papadopoulos, N., Martin, J., Ruan, Q., Rafique, A., Rosconi, M. P., Shi, E., ... & Wiegand, S. J. (2012). Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis, 15(2), 171-185.
Figure 2 Radiolabeled VEGF binding assay
[125I]VEGF was equilibrated (23 °C) with serial dilutions of unlabeled VEGF and (a) Fab-12 or (c) Y0317. Fabs were captured with an anti-Fab antibody-coated immunosorbant plate. Scatchard analysis (Munson & Rodbard, 1980) with a 1:1 binding model was used to calculate Kd of (b) 433 (116) pM for Fab-12 and (d) 19.8(4.3) pM for Y0317.
Clark, L. A., Boriack-Sjodin, P. A., Day, E., Eldredge, J., Fitch, C., Jarpe, M., ... & Van Vlijmen, H. W. (2008). An antibody loop replacement design feasibility study and a loop-swapped dimer structure. Protein Engineering, Design & Selection, 22(2), 93-101.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1036 | Recombinant Anti-VEGF Antibody | ELISA, WB, Dot, FuncS | IgG |
MHH-1036 | Recombinant Human Anti-VEGF Antibody | ELISA, WB, FC, FuncS | IgG |
HPAB-0746LY | Human Anti-VEGF Recombinant Antibody (HPAB-0746LY) | ELISA | Humanized IgG1 |
HPAB-2709LY | Human Anti-VEGF Recombinant Antibody (clone YS03) | ELISA | Human IgG |
HPAB-AP213-YC | Human Anti-VEGF Recombinant Antibody (HPAB-AP213-YC) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1036-S(P) | Recombinant Anti-VEGF Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
MHH-1036-S(P) | Recombinant Human Anti-VEGF Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
PSBZ-130 | Mouse Anti-VEGF Recombinant Antibody (clone 12); scFv Fragment | ELISA, Neut | Mouse scFv |
PSBW-130 | Mouse Anti-VEGF Recombinant Antibody (clone A4.6.1); scFv Fragment | Neut, ELISA | Mouse scFv |
HPAB-AP213-YC-S(P) | Human Anti-VEGF Recombinant Antibody; scFv Fragment (HPAB-AP213-YC-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-288CQ | Human Anti-VEGF Recombinant Antibody (TAB-288CQ) | ELISA | Chimeric (Mouse/Human) IgG1, κ |
TAB-301CQ | Human Anti-VEGF Recombinant Antibody (TAB-301CQ) | ELISA, FC, IHC, WB | Chimeric (Mouse/Human) IgG1, κ |
TAB-288CQ-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (TAB-288CQ-F(E)) | ELISA, WB, IHC, Block | Chimeric (Mouse/Human) Fab |
TAB-301CQ-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (TAB-301CQ-F(E)) | ELISA, FC, IHC, WB | Chimeric (Mouse/Human) Fab |
PABX-185-F (E) | Recombinant Mouse Anti-VEGF Antibody Fab Fragment (Fab-12) | ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-303CQ | Anti-Human VEGF Recombinant Antibody (EBV321) | ELISA, WB, Neut | |
TAB-285CQ-S(P) | Mouse Anti-VEGF Recombinant Antibody; scFv Fragment (TAB-285CQ-S(P)) | ELISA, WB, Neut | Mouse scFv |
TAB-287CQ-S(P) | Mouse Anti-VEGF Recombinant Antibody; scFv Fragment (TAB-287CQ-S(P)) | ELISA, WB, IHC, Block | Mouse scFv |
TAB-290CQ-S(P) | Anti-Human VEGF Recombinant Antibody scFv Fragment | ELISA, WB, Neut | |
TAB-303CQ-S(P) | Anti-Human VEGF Recombinant Antibody scFv Fragment (EBV321) | ELISA, WB, Neut |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-291CQ-S(P) | Anti-Human VEGF Recombinant Antibody scFv Fragment (3G6) | ELISA, Inhib | Human antibody |
TAB-292CQ-S(P) | Human Anti-VEGF Recombinant Antibody; scFv Fragment (TAB-292CQ-S(P)) | ELISA, Inhib | Human scFv |
TAB-296CQ-S(P) | Anti-Human VEGF Recombinant Antibody scFv Fragment (XPA.10.064) | ELISA, IHC, Inhib | Human antibody |
TAB-297CQ-S(P) | Anti-Human VEGF Recombinant Antibody scFv Fragment (XPA.10.072) | ELISA, IHC, Inhib | Human antibody |
TAB-286CQ-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (BD2) | ELISA, WB, Neut | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-289CQ-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (TAB-289CQ-F(E)) | ELISA, WB, IHC, Block | Humanized Fab |
TAB-293CQ-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (HAB1) | ELISA, Inhib | Humanized antibody |
TAB-294CQ-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (hAB2) | ELISA, Inhib | Humanized antibody |
TAB-295CQ-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (hAB3) | ELISA, Inhib | Humanized antibody |
TAB-302CQ-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (hEBV321) | ELISA, WB, Neut | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-096LC | Recombinant Anti-Human VEGF Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-143LC | Recombinant Anti-Human VEGF Antibody (Fc glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-179LC | Recombinant Anti-Human VEGF Antibody (Non-glycosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4485 | Rabbit Anti-VEGF Recombinant Antibody (clone SI581DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2806LY-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (HPAB-2806LY-F(E)) | ELISA, WB | Humanized Fab |
HPAB-2807LY-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (HPAB-2807LY-F(E)) | ELISA, WB | Humanized Fab |
HPAB-2808LY-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (HPAB-2808LY-F(E)) | ELISA, WB | Humanized Fab |
HPAB-2809LY-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (HPAB-2809LY-F(E)) | ELISA, WB | Humanized Fab |
HPAB-2810LY-F(E) | Human Anti-VEGF Recombinant Antibody; Fab Fragment (HPAB-2810LY-F(E)) | ELISA, WB | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-J0267-YC | Recombinant Camelid Anti-VEGF Single Domain Antibody (V9) | ELISA, Neut | Camelid VHH |
HPAB-J0268-YC | Recombinant Camelid Anti-VEGF Single Domain Antibody (V93) | ELISA, Neut | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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