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ZAP70

Recombinant Antibody Products Formats

Anti-ZAP70 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
ZAP70
Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (NK-cells, T-cells, dendritic cells)

Immune cell specificity

Group enriched (gdT-cell, NK-cell, memory CD8 T-cell, MAIT T-cell, T-reg, naive CD8 T-cell, memory CD4 T-cell, naive CD4 T-cell)

Cell line specificity

Group enriched (JURKAT, MOLT-4)

Interaction

Interacts with CD247/CD3Z; this interaction docks ZAP70 at the stimulated TCR (PubMed:1423621, 7659156, 26783323). Interacts with NFAM1 (PubMed:15143214). Interacts with adapter protein SLA; this interaction negatively regulates T-cell receptor signaling (PubMed:10449770). Interacts with FCRL3 (PubMed:12051764, 19843936). Interacts with VAV1 (PubMed:9151714). Interacts with CBL; this interaction promotes ubiquitination, internalization and subsequent degradation of CD247/CD3Z (PubMed:10449770, 10078535). Identified in a complex with CBL and UBE2L3 (PubMed:10966114). Interacts with SHB (PubMed:12084069). Interacts with adapter protein SLA2; this interaction negatively regulates T-cell receptor signaling. Interacts with CBLB. Interacts (via SH2 domains) with RHOH; this interaction regulates ZAP70 subcellular localization. Interacts with DEF6 (By similarity). Interacts (ubiquitinated form) with OTUD7B and UBASH3B (PubMed:26903241).

Molecular function

Kinase, Transferase, Tyrosine-protein kinase

More Types Infomation
Related Signaling Pathways
BCR Signaling Pathway BCR Signaling Pathway
TCR Signaling Pathway TCR Signaling Pathway
Related Diseases
Primary Immunodeficiency Primary Immunodeficiency
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