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ZAP70
Loading...Anti-ZAP70 Products
- Rabbit Anti-ZAP70 Recombinant Antibody (clone JU08-39) (MRO-1610-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC, IP
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- Recombinant Mouse Anti-ZAP70 Antibody (clone 1F3G9) (VS3-FY1572)
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- Type: Mouse IgG1
- Application: ELISA, WB
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- Recombinant Mouse Anti-ZAP70 Antibody (clone 6D9C2) (VS3-FY1573)
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- Type: Mouse IgG1
- Application: ELISA, WB, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-ZAP70 Monoclonal Antibody (clone 3D2A4) (VS7-0425-WR1146)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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- Mouse Anti-ZAP70 Monoclonal Antibody (VS7-0425-WR1147) (VS7-0425-WR1147)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC-P, IF, ELISA
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- Anti-ZAP70 Immunohistochemistry Kit (VS-0525-XY7999)
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- Species Reactivity: Human
- Target: ZAP70
- Application: IHC
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- Anti-Mouse ZAP70 Immunohistochemistry Kit (VS-0525-XY8000)
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- Species Reactivity: Human, Mouse, Rat
- Target: ZAP70
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (NK-cells, T-cells, dendritic cells)
Immune cell specificity
Group enriched (gdT-cell, NK-cell, memory CD8 T-cell, MAIT T-cell, T-reg, naive CD8 T-cell, memory CD4 T-cell, naive CD4 T-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4)
Interaction
Interacts with CD247/CD3Z; this interaction docks ZAP70 at the stimulated TCR (PubMed:1423621, 7659156, 26783323). Interacts with NFAM1 (PubMed:15143214). Interacts with adapter protein SLA; this interaction negatively regulates T-cell receptor signaling (PubMed:10449770). Interacts with FCRL3 (PubMed:12051764, 19843936). Interacts with VAV1 (PubMed:9151714). Interacts with CBL; this interaction promotes ubiquitination, internalization and subsequent degradation of CD247/CD3Z (PubMed:10449770, 10078535). Identified in a complex with CBL and UBE2L3 (PubMed:10966114). Interacts with SHB (PubMed:12084069). Interacts with adapter protein SLA2; this interaction negatively regulates T-cell receptor signaling. Interacts with CBLB. Interacts (via SH2 domains) with RHOH; this interaction regulates ZAP70 subcellular localization. Interacts with DEF6 (By similarity). Interacts (ubiquitinated form) with OTUD7B and UBASH3B (PubMed:26903241).
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
Related Signaling Pathways
BCR Signaling Pathway
TCR Signaling Pathway
Related Diseases
Primary Immunodeficiency