transferrin-RTA immunotoxin
CAT#: AGTO-L076R
This immunotoxin was achieved by conjugating/fusing the transferrin to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TFRC expressing cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to endosomes & lysosomes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28598/546_F8_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/207_B2_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/208_B2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Pachytene spermatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_6_6.jpg
Normal Tissue
Figure 7 Bone marrow
Hematopoietic cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_6_4.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072274-TFRC
❮
❯
Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- transferrin-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
- Alternative Names
- CD 71; CD71; CD71 antigen; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; p90; sTfR; T9; TFR 1; TfR; TfR1; TFR1_HUMAN; TFRC; TR; Transferrin receptor (p90 CD71); Transferrin receptor protein 1, serum form; Trfr; T cell leukemias; lymphomas; graft- versus-host diseases; autoimmune diseases; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 7037
- UniProt ID
- P02786
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G067E | Anti-TFRC immunotoxin HB21 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G067D | Anti-TFRC immunotoxin HB21 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G067G | Anti-TFRC immunotoxin HB21 (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G067R | Anti-TFRC immunotoxin HB21 (scFv)-RTA | Cytotoxicity assay, Function study | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0464CL | Mouse Anti-TFRC Recombinant Antibody (TAB-0464CL) | FuncS | Mouse IgG |
| TAB-0465CL | Mouse Anti-TFRC Recombinant Antibody (TAB-0465CL) | FuncS | Mouse IgG |
| TAB-0466CL | Mouse Anti-TFRC Recombinant Antibody (TAB-0466CL) | FuncS | Mouse IgG |
| TAB-615CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (6-90) | ELISA, WB, IP | |
| TAB-616CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (55-31) | ELISA, WB, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-611CT | Humanized Anti-TFRC Recombinant Antibody (TAB-611CT) | ELISA | Humanized IgG |
| TAB-611CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-611CT-S(P)) | ELISA | Humanized scFv |
| TAB-612CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-612CT-S(P)) | ELISA | Humanized scFv |
| TAB-613CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-613CT-S(P)) | ELISA | Humanized scFv |
| TAB-614CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-614CT-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-615CT | Anti-Human TfR Recombinant Antibody (6-90) | ELISA, WB, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-619CT | Human Anti-TFRC Recombinant Antibody (TAB-619CT) | ELISA, WB | Human antibody |
| TAB-620CT | Human Anti-TFRC Recombinant Antibody (TAB-620CT) | ELISA, WB | Human antibody |
| TAB-621CT | Anti-Human TfR Recombinant Antibody (LUCA31) | ELISA, WB, FC | Human antibody |
| TAB-623CT | Anti-Human TfR Recombinant Antibody (3TF12) | WB | Human antibody |
| TAB-624CT | Anti-Human TfR Recombinant Antibody (3TF2) | WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0036MZ | Recombinant Mouse Anti-Human TFRC Antibody (clone A8-2) | ELISA, WB | Mouse antibody |
| FAMAB-0281YC | Mouse Anti-TFRC Recombinant Antibody (clone OX26) | ELISA | Mouse IgG |
| HPAB-2692LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2692LY) | ELISA | Mouse IgG |
| HPAB-2693LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2693LY) | ELISA | Mouse IgG |
| HPAB-2694LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2694LY) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1999CQ | Rat Anti-Tfrc Recombinant Antibody (clone RI7217) | FC, ICC, IP, WB, Block | Rat IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3548 | Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) | FC, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3370 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTGKL) MHC Tetramer | FCM | |
| MHC-LC3371 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0376-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0376-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0377-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0377-CN-S(P)) | ELISA, FC | Mouse scFv |
| FAMAB-0281-YC-S(P) | Mouse Anti-TFRC Recombinant Antibody (clone OX26); scFv Fragment | ELISA | Mouse scFv |
| HPAB-597-FY-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-597-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-2579LY-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-2579LY-S(P)) | ELISA | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0376-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0376-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0377-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0377-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0378-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0378-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0379-CN-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0379-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0380-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody Fab Fragment (HPAB-0380-CN-F(E)) | ELISA, FC, IF, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1481 | AbPlus™ Anti-TFRC Magnetic Beads (VS-0724-YC1481) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY205 | CytoStream™ Mouse Anti-TFRC Recombinant Antibody (clone OX-26) | FC, IHC, IP | Mouse IgG2a, kappa |
| VS-0225-XY206 | CytoStream™ Rat Anti-TFRC Recombinant Antibody (clone RI7217) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC571 | Recombinant Anti-TFRC Vesicular Antibody, EV Displayed (VS-0425-YC571) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7200 | Anti-Mouse TFRC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7201 | Anti-Rat TFRC Immunohistochemistry Kit | IHC |
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