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transferrin-RTA immunotoxin (AGTO-L076R)

This immunotoxin was achieved by conjugating/fusing the transferrin to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TFRC expressing cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.      
  • Datasheet

Specifications
Host
Human
Species Reactivity
Human
Molecule Class
transferrin-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
Alternative Names
CD 71; CD71; CD71 antigen; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; p90; sTfR
Entrez Gene ID
7037
UniProt ID
P02786

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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