transferrin-RTA immunotoxin
CAT#: AGTO-L076R
This immunotoxin was achieved by conjugating/fusing the transferrin to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TFRC expressing cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.










Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- transferrin-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
- Alternative Names
- CD 71; CD71; CD71 antigen; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; p90; sTfR; T9; TFR 1; TfR; TfR1; TFR1_HUMAN; TFRC; TR; Transferrin receptor (p90 CD71); Transferrin receptor protein 1, serum form; Trfr; T cell leukemias; lymphomas; graft- versus-host diseases; autoimmune diseases; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 7037
- UniProt ID
- P02786
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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CAT | Product Name | Application | Type |
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TAB-612CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-612CT-S(P)) | ELISA | Humanized scFv |
TAB-613CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-613CT-S(P)) | ELISA | Humanized scFv |
TAB-614CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-614CT-S(P)) | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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TAB-619CT | Human Anti-TFRC Recombinant Antibody (TAB-619CT) | ELISA, WB | Human antibody |
TAB-620CT | Human Anti-TFRC Recombinant Antibody (TAB-620CT) | ELISA, WB | Human antibody |
TAB-621CT | Anti-Human TfR Recombinant Antibody (LUCA31) | ELISA, WB, FC | Human antibody |
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HPAB-2694LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2694LY) | ELISA | Mouse IgG |
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MOR-3548 | Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) | FC, IP, WB | Rabbit IgG |
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MHC-LC3370 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTGKL) MHC Tetramer | FCM | |
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CAT | Product Name | Application | Type |
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HPAB-0376-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0376-CN-S(P)) | ELISA, FC | Mouse scFv |
HPAB-0377-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0377-CN-S(P)) | ELISA, FC | Mouse scFv |
FAMAB-0281-YC-S(P) | Mouse Anti-TFRC Recombinant Antibody (clone OX26); scFv Fragment | ELISA | Mouse scFv |
HPAB-597-FY-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-597-FY-S(P)) | ELISA | Humanized scFv |
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CAT | Product Name | Application | Type |
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HPAB-0376-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0376-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0377-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0377-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0378-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0378-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0379-CN-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0379-CN-F(E)) | ELISA, FC | Humanized Fab |
HPAB-0380-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody Fab Fragment (HPAB-0380-CN-F(E)) | ELISA, FC, IF, IP | Mouse Fab |
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CAT | Product Name | Application | Type |
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VS-0225-XY206 | CytoStream™ Rat Anti-TFRC Recombinant Antibody (clone RI7217) | FC | Rat IgG2a, kappa |
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VS-0425-YC571 | Recombinant Anti-TFRC Vesicular Antibody, EV Displayed (VS-0425-YC571) | ELISA, FC, Cell-uptake |
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VS-0525-XY7201 | Anti-Rat TFRC Immunohistochemistry Kit | IHC |
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