10-FnIII scaffold protein anti-Human Proprotein convertase subtilisin kexin-9 (PCSK9) (CAT#: SFN-L018)

The tenth fibronectin type III domain (10Fn3) that bound Proprotein convertase subtilisin kexin-9 (PCSK9) was isolated from the library using phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=1.2 nM) for Proprotein convertase subtilisin kexin-9 (PCSK9) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.