Recombinant Anti-PCSK9 Eliminating Antibody, pH-Sensitive (VS-0625-YC248)
CAT#: VS-0625-YC248
The anti-PCSK9 eliminating antibody is an engineered pH-sensitive antibody against human PCSK9. PCSK9, involved in cholesterol regulation, has implications in fetal development and cancer growth. The antibody has a novel PCSK9-sweeping activity in vivo, which selectively eliminatesthe soluble PCSK9 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A-431, CACO-2, HaCaT, HeLa, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169174-PCSK9
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG2 kappa
- Specificity
- Human PCSK9
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0625-YC248. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PCSK9"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H31 | Human Anti-PCSK9 Recombinant Antibody (TAB-H31) | FC, IP, ELISA, Neut, FuncS, IF, IHC | Human IgG2, λ |
| TAB-0953CL | Human Anti-PCSK9 Recombinant Antibody (TAB-0953CL) | ELISA | Human IgG1 |
| TAB-0954CL | Human Anti-PCSK9 Recombinant Antibody (TAB-0954CL) | WB | Human IgG |
| TAB-0955CL | Mouse Anti-PCSK9 Recombinant Antibody (TAB-0955CL) | WB | Mouse IgG |
| TAB-0959CL | Human Anti-PCSK9 Recombinant Antibody (TAB-0959CL) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-758 | Anti-PCSK9 Recombinant Antibody (Lodelcizumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-H10 | Anti-Human PCSK9 Recombinant Antibody (Bococizumab) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG2 - kappa |
| TAB-764CL | Human Anti-PCSK9 Recombinant Antibody (TAB-764CL) | ELISA | Human IgG |
| TAB-0957CL | Anti-Human PCSK9 Recombinant Antibody (h7F8) | ELISA | Humanized antibody |
| TAB-0958CL | Anti-Human PCSK9 Recombinant Antibody (h7F8ml2) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-101 | Human Anti-PCSK9 Recombinant Antibody (clone 1D05); Fab Fragment | ELISA, WB, Neut | Human Fab |
| HPAB-667-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-667-FY-F(E)) | Inhib | Human Fab |
| HPAB-668-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-668-FY-F(E)) | Inhib | Human Fab |
| HPAB-2454LY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-2454LY-F(E)) | ELISA, Inhib | Chimeric (mouse/human) Fab |
| HPAB-2455LY-F(E) | Human Anti-PCSK9 Recombinant Antibody (clone 8D8F); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0956CL | Anti-Human PCSK9 Recombinant Antibody (m7F8) | ELISA | |
| TAB-0960CL | Anti-Human PCSK9 Recombinant Antibody (Ab1) | ELISA | Rabbit mAb |
| TAB-0956CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (m7F8) | ELISA | |
| TAB-0956CL-F(E) | Anti-Human PCSK9 Recombinant Antibody Fab Fragment (m7F8) | ELISA | |
| TAB-0960CL-F(E) | Anti-Human PCSK9 Recombinant Antibody Fab Fragment (Ab1) | ELISA | Rabbit mAb |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0080CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0080CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0081CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0081CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0082CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0082CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0083CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0083CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| TAB-0084CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (TAB-0084CL-VHH) | FuncS, Inhib, FC, WB | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1826CQ | Recombinant Human Anti-PCSK9 Antibody, Unconjugated | Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2618 | Hi-Affi™ Recombinant Rabbit Anti-PCSK9 Monoclonal Antibody (DS2618AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0234-YC | Mouse Anti-PCSK9 Recombinant Antibody (HPAB-0234-YC) | ELISA, FuncS | Mouse IgG |
| HPAB-0041-WJ | Mouse Anti-PCSK9 Recombinant Antibody (clone Ab-3D5) | ELISA, WB, Inhib | Mouse IgG, κ |
| HPAB-667-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-667-FY) | Inhib, SPR, ELISA | Human IgG2 |
| HPAB-668-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-668-FY) | Inhib, SPR | Human IgG2 |
| HPAB-M0175-YC | Mouse Anti-PCSK9 Recombinant Antibody (clone M/YC-8) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-758 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-758) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-H10 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H10) | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
| AFC-TAB-H59 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H59) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-H31 | Afuco™ Anti-PCSK9 Recombinant Antibody (AFC-TAB-H31), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0907-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody Fab Fragment (HPAB-0907-FY-F(E)) | Inhib | Humanized Fab |
| HPAB-1373-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1373-FY-F(E)) | ELISA | Human Fab |
| HPAB-1374-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1374-FY-F(E)) | ELISA | Human Fab |
| HPAB-1375-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1375-FY-F(E)) | ELISA | Human Fab |
| HPAB-1376-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1376-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY208 | AbPlus™ Anti-PCSK9 Magnetic Beads (VS-0424-XY208) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY208 | Human Anti-PCSK9 scFv-Fc Chimera (VS-0325-FY208) | WB, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5250 | Anti-PCSK9 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC142 | Recombinant Anti-PCSK9 (AA 31-152 x AA 213-219) Biparatopic Antibody, Tandem scFv (Clone 6E2 x Clone 3D5) | ELISA | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
-2.png)
Application: IB, ELISA, FC, FuncS
Application: ELISA, WB, Neut, Funcs, IHC, Inhib
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, Inhib, FC, Neut
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
