SmartAb™ Recombinant Anti-PCSK9 pH-dependent Antibody (Clone Lodelcizumab)

Name: SmartAb™ Recombinant Anti-PCSK9 pH-dependent Antibody (Clone Lodelcizumab)
SKU: VS-0825-YC277
Rating: 5 (1 reviews)

CAT#: VS-0825-YC277

The antibody binds to human PCSK9 with pH-dependent antigen binding properties. The antibody preferred PCSK9 binding under the acidic pH relative to physiological pH by introducing His mutations, which could act as a pH-switch. By employing yeast surface display with a pH-dependent screening pressure, mAbs having markedly increased dissociation from PCSK9 at pH 6.0 were identified. The pH-sensitive antibody maintained a binding affinity on tumor cells, while having negligible binding to PCSK9 expressed on normal cells under physiological pH. Human PCSK9, or Proprotein convertase subtilisin/kexin type 9, is an enzyme that regulates the level of LDL cholesterol in the blood. It binds to and promotes the degradation of the LDL receptor, resulting in higher blood levels of LDL cholesterol.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (A-431, CACO-2, HaCaT, HeLa, RPTEC TERT1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169174-PCSK9

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Specifications

Host Species
Human

Derivation
Humanized (from mouse)

Type
Human IgG1 kappa

Specificity
Human PCSK9

Species Reactivity
Human

Clone
Lodelcizumab

Applications
ELISA, FC, IP IF, Neut, ICC

Product Property

Clonality
Monoclonal

Purification
Protein A purified

Purity
>95%, determined by SDS-PAGE and SEC-HPLC

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.

Target

Alternative Names
PCSK9; proprotein convertase subtilisin/kexin type 9; HCHOLA3, hypercholesterolemia, autosomal dominant 3; FH3; NARC 1; NARC1; NARC-1; HCHOLA3;

Gene ID
353175

UniProt ID
Q8NBP7

Long Name
Proprotein Convertase Subtilisin/Kexin Type 9

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0825-YC277.pdf

MSDS

MSDS - VS-0825-YC277.pdf

COA

Certificate of Analysis Lookup

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