What is the purity of this Lodelcizumab antibody?

This recombinant antibody has a purity of greater than 97% as determined by SDS-PAGE under reducing conditions and visualized by silver stain. It is a humanized IgG1 kappa antibody expressed in CHO cells and is suitable for various immunological methods.

Can this antibody be used for functional assays?

Yes, this antibody is suitable for Functional Studies (FuncS), as well as ELISA, Flow Cytometry (FC), Immunoprecipitation (IP), Immunofluorescence (IF), Neutralization (Neut), and Immunocytochemistry (ICC). It binds to human PCSK9, a protein involved in cholesterol metabolism.

Anti-PCSK9 Recombinant Antibody (Lodelcizumab)

CAT#: TAB-758

Recombinant humanized antibody expressed in CHO binding to human PCSK9. Lodelcizumab is a monoclonal antibodiess for the treatment of hypercholesterolemia.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced (A-431, CACO-2, HaCaT, HeLa, RPTEC TERT1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169174-PCSK9

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Humanized (from mouse)

Type
IgG1 - kappa

Species Reactivity
Human

Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.

Generic Name
lodelcizumab

Related Disease
Hypercholesterolemia

Product Property

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Target

Alternative Names
lodelcizumab;LFU720;pJG04;PCSK9;proprotein convertase subtilisin/kexin type 9;HCHOLA3, hypercholesterolemia, autosomal dominant 3;FH3;NARC 1;NARC1;NARC-1;HCHOLA3;

Gene ID
353175

UniProt ID
Q8NBP7

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Breast cancer biomarkers at key points during disease progression

Excellent Functional Assay Results

We utilized Lodelcizumab for functional assays regarding cholesterol metabolism research. The antibody showed high purity, greater than 97 percent by SDS-PAGE, and behaved exactly as expected for a humanized IgG1 antibody in our inhibition studies.

Versatile Application Support

This antibody is incredibly versatile. We have tested it in both Immunofluorescence and Flow Cytometry with great success. It specifically binds to human PCSK9, making it an essential reagent for our lab's investigation into proprotein convertase family enzymes.

Q&As

What is the purity of this Lodelcizumab antibody?

A: This recombinant antibody has a purity of greater than 97% as determined by SDS-PAGE under reducing conditions and visualized by silver stain. It is a humanized IgG1 kappa antibody expressed in CHO cells and is suitable for various immunological methods.
Can this antibody be used for functional assays?

A: Yes, this antibody is suitable for Functional Studies (FuncS), as well as ELISA, Flow Cytometry (FC), Immunoprecipitation (IP), Immunofluorescence (IF), Neutralization (Neut), and Immunocytochemistry (ICC). It binds to human PCSK9, a protein involved in cholesterol metabolism.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-758.pdf

MSDS

MSDS - TAB-758.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "lodelcizumab"

Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-758)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human PCSK9. It is a monoclonal antibodiess for the treatment of hypercholesterolemia.

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