Anti-B7H4 (clone 2A7)-MED-Toxin B ADC (CAT#: ADC-259CL)
This ADC product is composed of an anti-B7H4 antibody (clone 2A7) conjugated via MED linker to Toxin B(2A7-MED-Toxin B).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression

Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/1356_C9_3_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/1356_C9_3_selected.jpg

Figure 2 IHC staining of human breast
(Immunohistochemical staining of human breast shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/ihc_selected.jpg
(Immunohistochemical staining of human breast shows moderate membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/ihc_selected.jpg

Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_9_3.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_9_3.jpg

Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_8_5.jpg

Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_4_6.jpg

Figure 6 Breast
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_B_3_4.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_B_3_4.jpg

Figure 7 Lymph node
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_7_8.jpg
(Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_7_8.jpg

Figure 8 RNA cell line category: Cell line enriched (SK-BR-3)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134258-VTCN1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134258-VTCN1
Specifications
- Antibody Overview
- Anti-B7H4 HuMAb 2A7
- Clone
- 2A7
- Linker
- MED
- Drug
- Toxin B
Target
- Introduction
- This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- Alternative Names
- VTCN1; V-set domain containing T cell activation inhibitor 1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; V-set domain-containing T-cell activation inhibitor 1; B7 homolog 4; B7 family member, H4; B7 superfamily member 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4;
- Gene ID
- 79679
- UniProt ID
- Q7Z7D3
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 2A7"
See other products for "VTCN1"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Chimeric Antibody Products
IgM Antibody Products
Mouse Antibody Products
Humanized Antibody Products
Human Antibody Products
ScFv Antibody Products
Neutralizing Antibody Products
Rabbit Monoclonal Antibody Products
Fab Antibody Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
Extracellular Vesicle (EV) Antibody Products
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2216z | Mouse Anti-VTCN1 Recombinant Antibody (clone 21A2) | WB, ELISA | Mouse IgG1 |
TAB-1120CL | Human Anti-VTCN1 Recombinant Antibody (TAB-1120CL) | FuncS | Human IgG |
FN-218CQ | Mouse Anti-VTCN1 Recombinant Antibody (clone H74) | FC, FuncS | Mouse IgG1, κ |
HPAB-N0297-YC | Mouse Anti-VTCN1 Recombinant Antibody (clone B7H4/1E10) | ELISA, WB | Mouse IgG |
VS3-FY1549 | Recombinant Rabbit Anti-VTCN1 Antibody (clone R08-7G4) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for ADC-259CL. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: FC, IB, Block, Inhib, FuncS, ELISA, FACS, IP, IF
Application: ELISA, FC, IHC, Neut
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.