Anti-B7H4 (clone 2A7)-MED-Toxin B ADC
CAT#: ADC-259CL
This ADC product is composed of an anti-B7H4 antibody (clone 2A7) conjugated via MED linker to Toxin B(2A7-MED-Toxin B).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/1356_C9_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human breast
Immunohistochemical staining of human breast shows moderate membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_4_6.jpg
Normal Tissue
Figure 6 Breast
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_B_3_4.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54200/147470_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enriched (SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134258-VTCN1
❮
❯
Specifications
- Antibody Overview
- Anti-B7H4 HuMAb 2A7
- Clone
- 2A7
- Linker
- MED
- Drug
- Toxin B
Target
- Introduction
- This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- Alternative Names
- VTCN1; V-set domain containing T cell activation inhibitor 1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; V-set domain-containing T-cell activation inhibitor 1; B7 homolog 4; B7 family member, H4; B7 superfamily member 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4;
- Gene ID
- 79679
- UniProt ID
- Q7Z7D3
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-259CL. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 2A7"
- CAT
- Product Name
See other products for "VTCN1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1116CL | Mouse Anti-VTCN1 Recombinant Antibody (TAB-1116CL) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1110CL-S(P) | Human Anti-VTCN1 Recombinant Antibody; scFv Fragment (TAB-1110CL-S(P)) | ELISA, FC | Human scFv |
| TAB-1112CL-S(P) | Human Anti-VTCN1 Recombinant Antibody; scFv Fragment (TAB-1112CL-S(P)) | ELISA, FC | Human scFv |
| TAB-1110CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1110CL-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
| TAB-1112CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1112CL-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
| TAB-1114CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1114CL-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1101CL-F(E) | Mouse Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1101CL-F(E)) | ELISA, WB, FC, FuncS | Mouse Fab |
| TAB-1109CL-F(E) | Mouse Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1109CL-F(E)) | ELISA, FC | Mouse Fab |
| TAB-1111CL-F(E) | Mouse Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1111CL-F(E)) | ELISA, FC | Mouse Fab |
| TAB-1113CL-F(E) | Mouse Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1113CL-F(E)) | ELISA, FC | Mouse Fab |
| TAB-1115CL-F(E) | Mouse Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1115CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1102CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1102CL-F(E)) | ELISA | Humanized Fab |
| TAB-1103CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1103CL-F(E)) | ELISA | Humanized Fab |
| TAB-1104CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1104CL-F(E)) | ELISA | Humanized Fab |
| TAB-1105CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1105CL-F(E)) | ELISA | Humanized Fab |
| TAB-1106CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1106CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1117CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1117CL-F(E)) | ELISA, FC, FuncS | Human Fab |
| TAB-1118CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1118CL-F(E)) | ELISA, FC, FuncS | Human Fab |
| TAB-1119CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1119CL-F(E)) | ELISA, FC, FuncS | Human Fab |
| TAB-1121CL-F(E) | Anti-Human VTCN1 Recombinant Antibody Fab Fragment (11G1) | ELISA | Fully human antibody |
| TAB-1122CL-F(E) | Anti-Human VTCN1 Recombinant Antibody Fab Fragment (2A7) | ELISA | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1120CL-F(E) | Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1120CL-F(E)) | FuncS | Human Fab |
| HPAB-0335CQ-F(E) | Human Anti-VTCN1 Recombinant Antibody Fab Fragment (HPAB-0335CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0336CQ-F(E) | Human Anti-VTCN1 Recombinant Antibody Fab Fragment (HPAB-0336CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0337CQ-F(E) | Human Anti-VTCN1 Recombinant Antibody Fab Fragment (HPAB-0337CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-N0297-YC-F(E) | Mouse Anti-VTCN1 Recombinant Antibody (clone B7H4/1E10); Fab Fragment | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2275CQ | Rat Anti-Vtcn1 Recombinant Antibody (clone 188) | FC, FuncS, Neut | Rat IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3857 | Rabbit Anti-VTCN1 Recombinant Antibody (clone DS3857AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0307-CN | Mouse Anti-VTCN1 Recombinant Antibody (HPAB-0307-CN) | ELISA, FC, IHC, IF | Mouse IgG |
| HPAB-N0405-YC | Mouse Anti-VTCN1 Recombinant Antibody (clone 278M1) | FC | Mouse IgG |
| HPAB-N0406-YC | Human Anti-VTCN1 Recombinant Antibody (clone 278M1 L2H2) | FC, Inhib | Human IgG |
| MRO-1675-CN | Rabbit Anti-VTCN1 Polyclonal Antibody (MRO-1675-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1676-CN | Rabbit Anti-VTCN1 Polyclonal Antibody (MRO-1676-CN) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0305-CN-S(P) | Mouse Anti-VTCN1 Recombinant Antibody (clone 5F6); scFv Fragment | ELISA, FC, IHC | Mouse scFv |
| HPAB-0306-CN-S(P) | Mouse Anti-VTCN1 Recombinant Antibody; scFv Fragment (HPAB-0306-CN-S(P)) | ELISA, FC, IHC, IF | Mouse scFv |
| HPAB-0307-CN-S(P) | Mouse Anti-VTCN1 Recombinant Antibody; scFv Fragment (HPAB-0307-CN-S(P)) | ELISA, FC, IHC, IF | Mouse scFv |
| HPAB-N0405-YC-S(P) | Mouse Anti-VTCN1 Recombinant Antibody (clone 278M1); scFv Fragment | FC | Mouse scFv |
| HPAB-N0406-YC-S(P) | Human Anti-VTCN1 Recombinant Antibody (clone 278M1 L2H2); scFv Fragment | FC, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY232 | CytoStream™ Mouse Anti-VTCN1 Recombinant Antibody (clone MIH43) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2478 | Anti-VTCN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC263 | Recombinant Anti-VTCN1 Vesicular Antibody, EV Displayed (VS-0425-YC263) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC193 | Recombinant Anti-VTCN1 (AA 167-176 x AA 177-181) Biparatopic Antibody, Tandem scFv | ELISA, FC | Tandem scFv |
| VS-0525-YC191 | Recombinant Anti-VTCN1 (AA 177-181 x AA 238-257) Biparatopic Antibody, Tandem scFv | ELISA, FC | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
-2.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
-3-1.png)
-2.png)
Application: WB, ELISA
Application: WB, ELISA, IF
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FuncS
Application: ELISA
Application: ELISA, WB, FC
Application: ELISA, FC, IF, IHC, WB
Application: WB, FC, IF, Inhib, ELISA, IHC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
