Anti-Human VTCN1 Recombinant Antibody (2A7) (CAT#: TAB-1122CL)
The anti-B7-H4 antibiody specifically binds B7-H4 also known as O8E, the antibody can be used in the treatment of cancer, such as ovarian cancer, lung cancer and breast cancer.
Specific Inquiry
ADCC
Figure 1 The results of antibody dependent cellular cytotoxicity (ADCC) assays demonstrating that human monoclonal anti-O8E antibodies kill O8E transfected SKOV3 cells in an ADCC dependent manner.
ADCC
Figure 2 The results of antibody dependent cellular cytotoxicity (ADCC) assays demonstrating that human monoclonal anti-O8E antibodies kill human breast cancer cell line SKBR3 in a concentration and ADCC dependent manner.
FuncS
Figure 3 The results of in vivo studies on SCID mice showing tumor growth inhibition of HEK-B7H4 tumors by anti-O8E antibodies.
FuncS
Figure 4 A graph showing the results of an in vivo HEK293-B7H4 xenograft mouse model, presenting median tumor volume in mice treated with vehicle alone, naked antibody, or antibody-partner molecule conjugates at various concentrations.
FuncS
Figure 5 A graph showing the results of an in vivo HEK293-B7H4 xenograft mouse model, presenting median body weight change in mice treated with vehicle alone, naked antibody, or antibody-partner molecule conjugates at various concentrations.
Specifications
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Clone
- 2A7
- Applications
- ADCC, FuncS
- Related Disease
- Ovarian cancer, Lung cancer, Breast cancer
Applications
- Application Notes
- This antibody has been tested for use in Antibody-dependent Cellular Cytotoxicity Assay and Functional Assay.
Target
- Alternative Names
- VTCN1; V-set domain containing T cell activation inhibitor 1; B7X; B7H4; B7S1; B7-H4; B7h. 5; VCTN1; PRO129
- Gene ID
- 79679
- UniProt ID
- Q7Z7D3
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1116CL | Mouse Anti-VTCN1 Recombinant Antibody (TAB-1116CL) | ELISA | Mouse IgM |
Customer Reviews and Q&As
Customer Review
Q&As
Reliable research reagent
The Anti-Human VTCN1 Recombinant Antibody (2A7) has contributed significantly to our understanding of tumor immune evasion. It detected VTCN1 in our in vitro models and proved to be a reliable study reagent.
Excellent clarity
Our research focuses on immune checkpoint proteins, and the Anti-Human VTCN1 Recombinant Antibody (2A7) provided excellent clarity in detecting VTCN1 interactions. The antibody's high affinity was evident in all our experimental protocols.
Applicable to various cancer cell lines
We've applied this antibody in a comparative study involving various cancer cell lines. It consistently identified VTCN1 expression levels, helping us correlate VTCN1 presence with cancer aggressiveness. A truly invaluable asset for our research.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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