APC-A*02:06/Human CEACAM5 (IMIGVLVGV) MHC Tetramer

CAT#: MHC-LC3086

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CEACAM5 of peptide IMIGVLVGV covering 691-699 and A*02:06 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression
Figure 1 IF staining of human cell line HaCaT Figure 2 IHC staining of human duodenum Figure 3 Colon Figure 4 Rectum Figure 5 RNA cell line category: Cell line enriched (OE19)

Specifications

  • Allele
  • A*02:06
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • CEACAM5
  • Antigen Species
  • Human
  • Peptide
  • IMIGVLVGV
  • Range
  • 691-699
  • Conjugate
  • APC

Target

  • Antigen Introduction
  • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • CEACAM5; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e
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