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    APC-A*02:06/Human CEACAM5 (IMIGVLVGV) MHC Tetramer (CAT#: MHC-LC3086)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CEACAM5 of peptide IMIGVLVGV covering 691-699 and A*02:06 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HaCaT
    Figure 1 IF staining of human cell line HaCaT
    (Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg
    Figure 2 IHC staining of human duodenum
    Figure 2 IHC staining of human duodenum
    (Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg
    Normal Tissue
    Figure 3 Colon
    Figure 3 Colon
    (Endocrine cells
    Staining: High
    Intensity: Strong
    Enterocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Enterocytes - Gradient
    Gradient: Ascending
    Enterocytes - Microvilli
    Staining: High
    Intensity: Strong
    Goblet cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Mucosal lymphoid cells
    Staining: Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg
    Figure 4 Rectum
    Figure 4 Rectum
    (Endocrine cells
    Staining: High
    Intensity: Strong
    Enterocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Enterocytes - Microvilli
    Staining: High
    Intensity: Strong
    Goblet cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Mucosal lymphoid cells
    Staining: Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg
    RNA Expression
    Figure 5 RNA cell line category: Cell line enriched (OE19)
    Figure 5 RNA cell line category: Cell line enriched (OE19)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5

    Specifications

    • Allele
    • A*02:06
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • CEACAM5
    • Antigen Species
    • Human
    • Peptide
    • IMIGVLVGV
    • Range
    • 691-699
    • Conjugate
    • APC
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
    • Alternative Names
    • CEACAM5; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e

    Downloads

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    CAT Product Name Application Type
    AGTO-L003E anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE Cytotoxicity assay, Functional assay
    AGTO-L003R anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA Cytotoxicity assay, Functional assay
    AGTO-L004E anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE Cytotoxicity assay, Functional assay
    AGTO-L004R anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA Cytotoxicity assay, Functional assay

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