Human Anti-CEACAM5 (clone MFE-23) scFv-Fc Chimera
CAT#: VS-0125-FY29
The anti-CEA scFv-Fc is a specialized antibody fragment designed specifically to target carcinoembryonic antigen (CEA), which is often overexpressed in pancreatic cancer cells. Its primary role is to improve the detection and imaging of pancreatic tumors, offering a highly sensitive approach that allows for better visualization of the disease during diagnostic procedures. Furthermore, due to its precise targeting capabilities, anti-CEA scFv-Fc shows promising potential not only in imaging but also in developing targeted therapies that could enhance treatment outcomes in patients with pancreatic cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg
Normal Tissue
Figure 4 Rectum
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
❮
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- MFE-23
- Applications
- Bioimaging
- Related Disease
- Pancreatic cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The function of anti-CEA scFv-Fc mainly serves as an antibody fragment targeting carcinoembryonic antigen (CEA), used for sensitive targeted imaging of pancreatic cancer and potential therapy. The primary function of anti-CEA scFv-Fc is to enhance the recognition and imaging of pancreatic cancer while demonstrating potential applications in targeted therapy through its targeting characteristics.
Target
- Alternative Names
- Carcinoembryonic Antigen Related Cell Adhesion Molecule 5; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5; Meconium Antigen 100; CEA; Carcinoembryonic Antigen; CD66e Antigen; CD66e
- Gene ID
- 1048
- UniProt ID
- P06731
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. CEA family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
- Protein Refseq
- NP_001278413.1; NP_001295327.1; NP_004354.3
- Function
- Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression.
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6.
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone MFE-23"
- CAT
- Product Name
See other products for "CEACAM5"
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-703 | Anti-Human CEACAM5 Recombinant Antibody (Altumomab) | IF, IP, Neut, FuncS, ELISA, FC, IHC | IgG1 |
| TAB-418LC-S(P) | Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 9) | FC, WB | |
| TAB-419LC-S(P) | Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 12) | FC, WB | |
| TAB-420LC-S(P) | Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 13) | FC, WB | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L003E | anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L003R | anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L004E | anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L004R | anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-409LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-409LC) | SPR, ELISA, FC | Humanized antibody |
| TAB-412LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-412LC) | ELISA, FC | Chimeric (Mouse/Human) IgG1 |
| TAB-409LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-409LC-S(P)) | SPR, ELISA, FC | Humanized scFv |
| TAB-412LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-412LC-S(P)) | FC, ELISA | Human scFv |
| TAB-413LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-413LC-S(P)) | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-410LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-410LC-S(P)) | ELISA | Humanized scFv |
| TAB-414LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-414LC-S(P)) | FC, ELISA | Human scFv |
| TAB-415LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-415LC-S(P)) | FC, ELISA | Human scFv |
| TAB-416LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-416LC-S(P)) | FC, ELISA | Human scFv |
| TAB-417LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-417LC-S(P)) | IF, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-411LC-S(P) | Human Anti-Human CEACAM5 Recombinant Antibody scFv Fragment | ELISA | Human antibody |
| TAB-411LC-F(E) | Human Anti-Human CEACAM5 Recombinant Antibody Fab Fragment | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0649 | Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P)) | Activ | Humanized scFv |
| HPAB-0243-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody scFv Fragment (HPAB-0243-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0348-YJ-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1094WJ-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-1094WJ-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-2106-FY-S(P) | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); scFv Fragment | ELISA, FC, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E)) | Activ | Humanized Fab |
| HPAB-0243-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody Fab Fragment (HPAB-0243-FY-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| HPAB-0348-YJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-1094WJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-2106-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); Fab Fragment | ELISA, FC, Inhib | Human Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0231-CN | Rabbit Anti-CEACAM5 Recombinant Antibody (clone JM93-28) | WB, IF, IHC | Rabbit IgG |
| FAMAB-1027CQ | Human Anti-CEACAM5 Recombinant Antibody (clone EB-022) | ELISA | Human IgG1 |
| FAMAB-1028CQ | Human Anti-CEACAM5 Recombinant Antibody (clone EB-011) | ELISA | Human IgG1 |
| HPAB-2106-FY | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6) | ELISA, FC, Inhib | Human IgG1, κ |
| VS-0723-WK269 | Rabbit Anti-CEACAM5 Recombinant Antibody (VS-0723-WK269) | ELISA, FC | Rabbit IgG |
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