anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA

Name: anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA
SKU: AGTO-L003R
Rating: 5 (1 reviews)

CAT#: AGTO-L003R

This immunotoxin was achieved by conjugating/fusing the Anti-CEACAM5 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to bladder carcinoma cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of bladder carcinoma.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg

Normal Tissue Figure 3 Colon

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg

Normal Tissue Figure 4 Rectum

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5

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Specifications

Host Species
Mouse

Species Reactivity
Human

Clone
BDI-1

Molecule Class
L kappa; IgG2a-RTA

Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.

Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.

Related Disease
Bladder carcinoma

Target

Alternative Names
CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100; Bladder carcinoma; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Gene ID
1048

UniProt ID
A0A024R0K5

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AGTO-L003R.pdf

MSDS

MSDS - AGTO-L003R.pdf

COA

Certificate of Analysis Lookup

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Product Name

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CAT	Product Name	Application
AGTO-L003E	anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE	Cytotoxicity assay, Functional assay
AGTO-L004E	anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE	Cytotoxicity assay, Functional assay
AGTO-L004R	anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
TAB-409LC	Human Anti-CEACAM5 Recombinant Antibody (TAB-409LC)	SPR, ELISA, FC	Humanized antibody
TAB-412LC	Human Anti-CEACAM5 Recombinant Antibody (TAB-412LC)	ELISA, FC	Chimeric (Mouse/Human) IgG1
TAB-413LC	Human Anti-CEACAM5 Recombinant Antibody (TAB-413LC)	Cyt, ELISA, FC, Inhib	Chimeric (Mouse/Human) IgG1
TAB-409LC-S(P)	Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-409LC-S(P))	SPR, ELISA, FC	Humanized scFv
TAB-412LC-S(P)	Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-412LC-S(P))	FC, ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-411LC-S(P)	Human Anti-Human CEACAM5 Recombinant Antibody scFv Fragment	ELISA	Human antibody
TAB-411LC-F(E)	Human Anti-Human CEACAM5 Recombinant Antibody Fab Fragment	ELISA	Human antibody

CAT	Product Name	Application
TAB-418LC-S(P)	Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 9)	FC, WB
TAB-419LC-S(P)	Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 12)	FC, WB
TAB-420LC-S(P)	Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 13)	FC, WB
TAB-421LC-S(P)	Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 15)	FC, WB
TAB-422LC-S(P)	Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 2)	FC, WB

CAT	Product Name	Application	Type
TAB-410LC-F(E)	Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-410LC-F(E))	ELISA	Humanized Fab
TAB-414LC-F(E)	Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-414LC-F(E))	FC, ELISA	Humanized Fab
TAB-415LC-F(E)	Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-415LC-F(E))	FC, ELISA	Humanized Fab
TAB-416LC-F(E)	Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-416LC-F(E))	FC, ELISA	Humanized Fab
TAB-417LC-F(E)	Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-417LC-F(E))	IF, ELISA	Humanized Fab

CAT	Product Name	Application	Type
TAB-002LC-VHH	Anti-Human CEACAM5 Recombinant Antibody(VHH library)	SPR, FC, ELISA	Single domain antibody
HPAB-0204-FY	Recombinant llama Anti-CEACAM5 Antibody (HPAB-0204-FY)	ADCC, ELISA	llama VHH
HPAB-0205-FY	Recombinant llama Anti-CEACAM5 Antibody (HPAB-0205-FY)	ADCC, E	llama VHH
HPAB-0206-FY	Recombinant llama Anti-CEACAM5 Antibody (HPAB-0206-FY)	ADCC, E	llama VHH
HPAB-1024WJ	Recombinant Camelid Anti-CEACAM5 Single Domain Antibody	SPR, Inhib	Camelid VHH

CAT	Product Name	Application	Type
MOB-0089MZ	Recombinant Mouse Anti-Carcinoembryonic antigen Antibody (clone A9203)	ELISA	Mouse antibody
MRO-1770-CN	Rabbit Anti-CEACAM5 Polyclonal Antibody (MRO-1770-CN)	WB, IF, IHC, FC	Rabbit IgG
VS3-QX225	Mouse Anti-CEACAM5 Recombinant Antibody (clone 1C7)	WB, IHC, ICC, FC, ELISA	Mouse IgG1
VS3-QX226	Mouse Anti-CEACAM5 Recombinant Antibody (clone 3G12)	WB, IHC, ICC, FC, ELISA	Mouse IgG1
VS3-WK1656	Recombinant Mouse Anti-CEACAM5 Capture Antibody (clone 15A12)	ELISA	Mouse IgG1

CAT	Product Name	Application	Type
BRD-0118MZ	Chicken Anti-CEACAM5 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application
MHC-LC137	PE-A*02:01/Human CEA (YLSGADLNL) MHC Tetramer	FCM
MHC-LC138	APC-A*02:01/Human CEA (YLSGADLNL) MHC Tetramer	FCM
MHC-LC165	BV421-A*02:01/Human CEA (YLSGANLNL) MHC Tetramer	FCM
MHC-LC166	APC-A*02:01/Human CEA (YLSGANLNL) MHC Tetramer	FCM
MHC-LC203	H-2Db/Human CEA (EAQNTTYL) MHC Tetramer	FCM

CAT	Product Name	Application	Type
MOR-0649	Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB)	IHC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0155-FY-S(P)	Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P))	Activ	Humanized scFv
HPAB-0243-FY-S(P)	Mouse Anti-CEACAM5 Recombinant Antibody scFv Fragment (HPAB-0243-FY-S(P))	ELISA	Mouse scFv
HPAB-0348-YJ-S(P)	Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); scFv Fragment	ELISA, IHC	Mouse scFv
HPAB-1094WJ-S(P)	Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-1094WJ-S(P))	ELISA, FC	Mouse scFv
HPAB-2106-FY-S(P)	Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); scFv Fragment	ELISA, FC, Inhib	Human scFv

CAT	Product Name	Application	Type
HPAB-0155-FY-F(E)	Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E))	Activ	Humanized Fab
HPAB-0243-FY-F(E)	Human Anti-CEACAM5 Recombinant Antibody Fab Fragment (HPAB-0243-FY-F(E))	ELISA	Chimeric (mouse/human) Fab
HPAB-0348-YJ-F(E)	Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); Fab Fragment	ELISA, IHC	Mouse Fab
HPAB-1094WJ-F(E)	Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E))	ELISA, FC	Mouse Fab
HPAB-2106-FY-F(E)	Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); Fab Fragment	ELISA, FC, Inhib	Human Fab, κ

CAT	Product Name	Application	Type
AFC-TAB-703	Afuco™ Anti-CEACAM5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-703)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-1024-XY62	Mouse Anti-NHP CEACAM5 Recombinant Antibody (clone SPM506)	IHC, IF, FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0125-FY29	Human Anti-CEACAM5 (clone MFE-23) scFv-Fc Chimera	BI	Human IgG1, scFv-Fc
VS-0125-FY89	Human Anti-CEACAM5 (clone A5B7) scFv-Fc Chimera	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC97	Recombinant Anti-CEACAM5 Vesicular Antibody, EV Displayed (VS-0425-YC97)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
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VS-0525-XY1356	Anti-Human CEACAM5 Immunohistochemistry Kit	IHC

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