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CEACAM5

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This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, Dot, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Target:
CEACAM5
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEA
Species Reactivity:
Human
Cytokine 1:
IL12
Host:
Human
Cytokine 1 Species:
Human
Molecule Class:
p40-scFv-p35
Target:
CD66e
Linker:
mc (maleimidocaproyl)
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Derivation:
Affinity Maturation Library
Type:
Humanized antibody
Application:
SPR, ELISA, FC
Derivation:
Humanized
Type:
Humanized antibody
Derivation:
ScFv phage-display librarie
Type:
Human antibody
Application:
ELISA
Derivation:
Chimeric (mouse/human)
Type:
Chimeric antibody (mouse/human)
Application:
FC, ELISA
Derivation:
Chimeric (mouse/human)
Type:
Chimeric antibody (mouse/human)
Application:
FC, ELISA
Derivation:
Phage display library
Type:
Humanized antibody
Application:
FC, ELISA
Derivation:
Phage display library
Type:
Humanized antibody
Application:
FC, ELISA
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