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CEACAM5

This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
  • Anti-CD66e-SN38 ADC (ADC-122LZY)

    • Target: CD66e
    • Linker: Phenylalanineelysine
    • Drug: SN-38(7-ethyl-10-hydroxy camptothecin)

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