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CEACAM5

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CEACAM5 (carcinoembryonic antigen-associated cell adhesion molecule 5), also known as CD66e, is a member of the Carcinoembryonic Antigen (CEA) gene family. This gene encodes a cell surface glycoprotein that represents a founding member of the Carcinoembryonic Antigen (CEA) protein family. The encoded protein is used as a clinical biomarker of gastrointestinal cancer and can contribute to tumor progression through its role as a cell adhesion molecule. In addition, the encoded proteins can regulate differentiation, apoptosis, and cell polarity. This gene is present in the CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. Labetuzumab (trade name CEA-CIDE) is a humanized IgGl monoclonal antibody for the treatment of colorectal cancer. It selectively binds to the oncoblast cell adhesion molecule 5.

Target:
CEACAM5
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Target:
CEACAM5
Linker:
CL2A
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, Dot, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1
Application:
IF, IP, Neut, FuncS, ELISA, FC, IHC
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
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