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CEACAM5

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This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IP, FC, FuncS, Neut, IF, ICC
Target:
CEACAM5
Drug:
SN-38 (7-ethyl-10-hydroxycamptothecin)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
Drug:
DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
Target:
CEACAM5
Linker:
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
Drug:
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, Dot, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB, FuncS
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, IHC, FC, FuncS
Target:
CEACAM5
Linker:
Phy-lys (Phenylalanine-lysine)
Drug:
SN-38(7-ethyl-10-hydroxy camptothecin)
Target:
CD66e
Linker:
Phenylalanineelysine
Drug:
SN-38(7-ethyl-10-hydroxy camptothecin)
Derivation:
Affinity Maturation Library
Type:
Humanized antibody
Application:
SPR, ELISA, FC
Derivation:
Humanized
Type:
Humanized antibody
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