anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE
CAT#: AGTO-L003E
This immunotoxin was achieved by conjugating/fusing the Anti-CEACAM5 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to bladder carcinoma cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of bladder carcinoma.





Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- BDI-1
- Molecule Class
- L kappa; IgG2a-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Bladder carcinoma
Target
- Alternative Names
- CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100; Bladder carcinoma; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35
- Gene ID
- 1048
- UniProt ID
- A0A024R0K5
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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- CAT
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CAT | Product Name | Application | Type |
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AGTO-L003R | anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L004E | anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE | Cytotoxicity assay, Functional assay | |
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TAB-409LC | Human Anti-CEACAM5 Recombinant Antibody (TAB-409LC) | SPR, ELISA, FC | Humanized antibody |
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TAB-409LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-409LC-S(P)) | SPR, ELISA, FC | Humanized scFv |
TAB-412LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-412LC-S(P)) | FC, ELISA | Human scFv |
CAT | Product Name | Application | Type |
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TAB-411LC-S(P) | Human Anti-Human CEACAM5 Recombinant Antibody scFv Fragment | ELISA | Human antibody |
TAB-411LC-F(E) | Human Anti-Human CEACAM5 Recombinant Antibody Fab Fragment | ELISA | Human antibody |
CAT | Product Name | Application | Type |
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TAB-410LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-410LC-F(E)) | ELISA | Humanized Fab |
TAB-414LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-414LC-F(E)) | FC, ELISA | Humanized Fab |
TAB-415LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-415LC-F(E)) | FC, ELISA | Humanized Fab |
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BRD-0118MZ | Chicken Anti-CEACAM5 Polyclonal IgY | WB | Chicken antibody |
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MOR-0649 | Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB) | IHC | Rabbit IgG |
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HPAB-0155-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P)) | Activ | Humanized scFv |
HPAB-0243-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody scFv Fragment (HPAB-0243-FY-S(P)) | ELISA | Mouse scFv |
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HPAB-0155-FY-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E)) | Activ | Humanized Fab |
HPAB-0243-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody Fab Fragment (HPAB-0243-FY-F(E)) | ELISA | Chimeric (mouse/human) Fab |
HPAB-0348-YJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); Fab Fragment | ELISA, IHC | Mouse Fab |
HPAB-1094WJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-2106-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); Fab Fragment | ELISA, FC, Inhib | Human Fab, κ |
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AFC-TAB-703 | Afuco™ Anti-CEACAM5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-703) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
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ZG-0067J | Mouse Anti-CEACAM5 Recombinant Antibody (clone 1E2) | IHC-P, IF, ICC | Mouse IgG |
ZG-0068J | Mouse Anti-CEACAM5 Recombinant Antibody (ZG-0068J) | IHC-P, IF | Mouse IgG |
VS3-CJ445 | Mouse Anti-CEACAM5 Recombinant Antibody (VS3-CJ445) | WB | Mouse IgG |
VS3-CJ446 | Mouse Anti-CEACAM5 Recombinant Antibody (clone ABT-CEA) | IHC-P | Mouse IgG2b, κ |
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