Anti-Human ADAMTS5 Recombinant Antibody Fab Fragment (CRB0094) (CAT#: TAB-0698CLV-F(E))
The anti-Sp_ADAMTS-5 antibody specifically binds to ADAMTS5 which is kind of aggrecanases of which the activities can result in the degradation of the cartilage matrix. By binding to the ADAMTS-5, the antibody can be used for the treatment of cartilage degradation, osteoarthritis and rheumatoid arthritis.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RH-30
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30906/if_selected.jpg
(Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30906/if_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5661/ihc_selected.jpg
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5661/ihc_selected.jpg
Figure 3 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows strong positivity in cytoplasm and cilia of glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/ihc_selected.jpg
(Immunohistochemical staining of human fallopian tube shows strong positivity in cytoplasm and cilia of glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/ihc_selected.jpg
Figure 4 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_3.jpg
Figure 5 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_8_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_8_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_4_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_4_6.jpg
Figure 7 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25996/58749_A_9_8.jpg
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, RH-30, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154736-ADAMTS5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154736-ADAMTS5
Specifications
- Immunogen
- Sp_ADAMTS-5
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Clone
- CRB0094
- Related Disease
- Cartilage degradation, osteoarthritis, rheumatoid arthritis
Target
- Alternative Names
- ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
- Gene ID
- 11096
- UniProt ID
- Q9UNA0
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-39 | Recombinant Anti-human ADAMTS5 Antibody | ELISA, WB, Dot, FuncS | IgG |
| MHH-39 | Recombinant Human Anti-human ADAMTS5 Antibody | ELISA, WB, FC, FuncS | IgG |
| MOB-142CQ | Mouse Anti-ADAMTS5 Recombinant Antibody (clone CBLS-195) | ELISA, WB, IP | Mouse IgG2b |
| HPAB-AP227-YC | Mouse Anti-ADAMTS5 Recombinant Antibody (HPAB-AP227-YC) | ELISA | Mouse IgG |
| HPAB-AP228-YC | Human Anti-ADAMTS5 Recombinant Antibody (HPAB-AP228-YC) | ELISA | Human IgG |
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