A monoclonal antibody that binds to the CD151 protein. This product is capable of inhibiting the development of primary tumors and of inhibiting its metastasispromoting activity. TS151 and TS151r behave similarly and they very significantly inhibit growth of the PC3 tumour implanted in a sub-cutaneous position in the Swiss Nude mouse.
Figure 1 Absence of free CD151 in resting HaCaT epithelial cells.
Staining of integrin α3 subunit (mAb P1B5, D) and CD151 (mAb TS151, E) shows both proteins in cell-cell contacts.
Chometon, G., Zhang, Z. G., Rubinstein, E., Boucheix, C., Mauch, C., & Aumailley, M. (2006). Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cells. Experimental cell research, 312(7), 983-995.
Figure 2 Treatment of HaCaT epithelial cells with mAb TS151r induces migration on laminin 1.
The distance covered by the cell front under the different conditions was measured on photographs. Each column represents the average of 10 measurements for two independent experiments, and the bars indicate standard deviation.
Chometon, G., Zhang, Z. G., Rubinstein, E., Boucheix, C., Mauch, C., & Aumailley, M. (2006). Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cells. Experimental cell research, 312(7), 983-995.
Figure 3 Differences in the abilities of anti-CD151 mAbs to co-precipitate integrin α3.
A549 cells were lysed in buffer containing 1 % Triton X-100 (A) or 1 % Brij 97 (B), and then subjected to immunoprecipitation with normal mouse IgG (Cont IgG) and ten anti-CD151 mAbs (8C3, TS151r, 14A2.H1, LIA1/1, VJ1/16, 14B5, SFA1.2B4, 11B1, 11G5 and TS151). The precipitates (IP) and 1/20 of the amounts of lysate proteins used for immunoprecipitation (TCL) were immunoblotted (IB) with anti-integrin α3 pAb, anti-EGFR pAb and biotinylated anti-CD151 mAb (8C3).
Yamada, M., Tamura, Y., Sanzen, N., Sato-Nishiuchi, R., Hasegawa, H., Ashman, L. K., ... & Sekiguchi, K. (2008). Probing the interaction of tetraspanin CD151 with integrin α3β1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151–integrin α3β1 complex. Biochemical Journal, 415(3), 417-427.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1623z | Mouse Anti-CD151 Recombinant Antibody (clone 24G4) | WB, FC, ICC, IHC, FuncS | Mouse IgG1 |
HPAB-0212-CN | Mouse Anti-CD151 Recombinant Antibody (clone TS151r) | FC, IP, IHC, IF, Inhib, WB | Mouse IgG |
HPAB-0214-CN | Mouse Anti-CD151 Recombinant Antibody (clone 9B) | WB, Co-IP, IF, IHC, Inhib, FuncS, FC, ELISA | Mouse IgG1 |
FAMAB-1034CQ | Human Anti-CD151 Recombinant Antibody (clone 11G5a) | IP, FC, FuncS, IHC | Human IgG1 |
VS3-XY208 | Mouse Anti-CD151 Recombinant Antibody (clone 3G1) | WB, IP, IF, IHC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1601CL | Anti-Human CD151 Recombinant Antibody (203B6) | FC, FuncS | |
TAB-1602CL | Anti-Human CD151 Recombinant Antibody (205H8) | FC, FuncS | |
TAB-1603CL | Anti-Human CD151 Recombinant Antibody (211F3) | FC, FuncS | |
TAB-1604CL | Anti-Human CD151 Recombinant Antibody (214B2) | FC, FuncS | |
TAB-1601CL-F(E) | Anti-Human CD151 Recombinant Antibody Fab Fragment (203B6) | FC, FuncS |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1605CL | Anti-Human CD151 Recombinant Antibody (c203B6) | ELISA, FC, WB | Chimeric antibody (mouse/human) |
TAB-1605CL-S(P) | Anti-Human CD151 Recombinant Antibody scFv Fragment (c203B6) | ELISA, FC, WB | Chimeric antibody (mouse/human) |
TAB-1606CL-S(P) | Anti-Human CD151 Recombinant Antibody scFv Fragment (c214B2) | ELISA, FC, WB, Block, FuncS | Chimeric antibody (mouse/human) |
TAB-1605CL-F(E) | Anti-Human CD151 Recombinant Antibody Fab Fragment (c203B6) | ELISA, FC, WB | Chimeric antibody (mouse/human) |
TAB-1606CL-F(E) | Anti-Human CD151 Recombinant Antibody Fab Fragment (c214B2) | ELISA, FC, WB, Block, FuncS | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1607CL | Anti-Human CD151 Recombinant Antibody (Humanized 203B6) | FC, FuncS, WB | Humanized antibody |
TAB-1608CL | Anti-Human CD151 Recombinant Antibody (Humanized 214B2) | FC, FuncS, WB | Humanized antibody |
TAB-1607CL-S(P) | Anti-Human CD151 Recombinant Antibody scFv Fragment (Humanized 203B6) | FC, FuncS, WB | Humanized antibody |
TAB-1608CL-S(P) | Anti-Human CD151 Recombinant Antibody scFv Fragment (Humanized 214B2) | FC, FuncS, WB | Humanized antibody |
TAB-1607CL-F(E) | Anti-Human CD151 Recombinant Antibody Fab Fragment (Humanized 203B6) | FC, FuncS, WB | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-285CQ | Mouse Anti-CD151 Recombinant Antibody (clone 50-6) | FC, ICC, WB, Block | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0533 | Hi-Affi™ Rabbit Anti-CD151 Recombinant Antibody (clone DS533AB) | WB, IHC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0212-CN-S(P) | Mouse Anti-CD151 Recombinant Antibody (clone TS151r); scFv Fragment | WB, FC, IHC, IP | Mouse scFv |
HPAB-0213-CN-S(P) | Mouse Anti-CD151 Recombinant Antibody (clone TS151); scFv Fragment | WB, FC, IHC, IP | Mouse scFv |
HPAB-0214-CN-S(P) | Mouse Anti-CD151 Recombinant Antibody (clone 9B); scFv Fragment | WB, ELISA, IHC, IF, Co-IP | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0212-CN-F(E) | Mouse Anti-CD151 Recombinant Antibody (clone TS151r); Fab Fragment | WB, FC, IHC, IP | Mouse Fab |
HPAB-0213-CN-F(E) | Mouse Anti-CD151 Recombinant Antibody (clone TS151); Fab Fragment | WB, FC, IHC, IP | Mouse Fab |
HPAB-0214-CN-F(E) | Mouse Anti-CD151 Recombinant Antibody (clone 9B); Fab Fragment | WB, ELISA, IHC, IF, Co-IP | Mouse Fab |
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