Anti-CD30 monoclonal antibody (MDX-1401) (CAT#: Gly-009CL)
MDX-1401 is a fully human, non-fucosylated antibody that targets CD30, a marker for activated lymphocytes that is present on malignant cells of HL as well as other CD30-expressing cancers.
Specific Inquiry
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
(Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
Figure 4 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
Figure 5 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
Figure 6 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
(Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
Normal Tissue
Figure 7 Colon
(Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
(Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
Figure 8 Appendix
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
(Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
Specifications
- Type
- Fully human Ab
- Class
- Antineoplastics; Monoclonal antibodies
- Mechanism of action
- CD30 antigen inhibitors; Immunostimulants
References
- Synonyms
- Lymphoma therapies; MDX-1401
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
| MOB-1158z | Mouse Anti-TNFRSF8 Recombinant Antibody (clone 19C10) | WB, FC, FuncS | Mouse IgG2b |
| HPAB-0445-CN | Mouse Anti-TNFRSF8 Recombinant Antibody (clone T105) | WB, ELISA, FC | Mouse IgG1 |
| HPAB-0447-CN | Mouse Anti-TNFRSF8 Recombinant Antibody (clone T405) | WB, ELISA | Mouse IgG2b |
| HPAB-0250-FY | Recombinant Human Anti-TNFRSF8 Antibody | F, IH | Human IgG1 |
| HPAB-1930-FY | Human Anti-TNFRSF8 Recombinant Antibody (clone 2H9) | ELISA, FC, ADCC | Human IgG |
Human Antibody
| CAT | Product Name | Application | Type |
| TAB-144 | Anti-Human CD30 Recombinant Antibody (Iratumumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
Chimeric Antibody
| CAT | Product Name | Application | Type |
| TAB-153 | Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (clone Brentuximab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG1, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
| AGTO-G062E | Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G062R | Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G062S | Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap | Cytotoxicity assay, Function study | |
| AGTO-L041E | anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L041R | anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA | Cytotoxicity assay, Functional assay |
Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-635CL | Human Anti-TNFRSF8 Recombinant Antibody (TAB-635CL) | ELISA | Human IgG |
| TAB-102LC | Anti-Human TNFRSF8 Recombinant Antibody | WB, FC, ELISA | Humanized antibody |
| TAB-103LC | Anti-Human TNFRSF8 Recombinant Antibody | WB, FC, ELISA | Humanized antibody |
| TAB-102LC-F(E) | Anti-Human TNFRSF8 Recombinant Antibody Fab Fragment | WB, FC, ELISA | Humanized antibody |
| TAB-103LC-F(E) | Anti-Human TNFRSF8 Recombinant Antibody Fab Fragment | WB, FC, ELISA | Humanized antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
| Gly-139LC | Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
| Gly-139LC-1 | Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
| BRD-0597MZ | Chicken Anti-TNFRSF8 Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
| NEUT-2165CQ | Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1) | FC, Stim, Costim, Block | Hamster IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
| NEUT-2166CQ | Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F) | Neut, FC | Hamster IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
| MOR-3617 | Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3617AB) | WB, IHC-P | Rabbit IgG |
| MOR-3618 | Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3618AB) | ELISA | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0329-YC-S(P) | Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0329-YC-S(P)) | ELISA, FC, Cyt, FuncS | Mouse scFv |
| HPAB-0330-YC-S(P) | Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0330-YC-S(P)) | ELISA, FC, Cyt, FuncS | Mouse scFv |
| HPAB-0331-YC-S(P) | Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0331-YC-S(P)) | ELISA, FC, Cyt, FuncS | Mouse scFv |
| HPAB-1929-FY-F(E) | Human Anti-TNFRSF8 Recombinant Antibody (clone 17G1); scFv Fragment | FC, ELISA | Human scFv |
| FAMAB-0358WJ-S(P) | Human Anti-TNFRSF8 Recombinant Antibody (clone AK30); scFv Fragment | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0329-YC-F(E) | Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0329-YC-F(E)) | ELISA, FC, Cyt, FuncS | Mouse Fab |
| HPAB-0445-CN-F(E) | Mouse Anti-TNFRSF8 Recombinant Antibody (clone T105); Fab Fragment | WB, ELISA, FC | Mouse Fab |
| HPAB-0447-CN-F(E) | Mouse Anti-TNFRSF8 Recombinant Antibody (clone T405); Fab Fragment | WB, ELISA | Mouse Fab |
| HPAB-1929-FY-S(P) | Human Anti-TNFRSF8 Recombinant Antibody (clone 17G1); Fab Fragment | FC, ELISA | Human Fab |
| HPAB-1930-FY-S(P) | Human Anti-TNFRSF8 Recombinant Antibody (clone 2H9); Fab Fragment | FC, ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
| AFC-TAB-144 | Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Iratumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-153 | Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Brentuximab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
AgonistAgonist
BABioassay
InhibInhibition
PGProteogenomics
StimStimulation
WBWestern Blot
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