Anti-CEACAM5-SN-38 ADC
CAT#: ADC-123CL
This ADC product is composed of an anti-CEACAM5 antibody conjugated via linker to SN-38(SN-38). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of Inhibiting Topoisomerase I and causing DNA damage.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg
Subcellular Location
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg
Normal Tissue
Figure 4 Rectum
Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
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Specifications
- Antibody Overview
- Humanized Antibody (Anti-CEACAM5)
- Drug
- SN-38 (7-ethyl-10-hydroxycamptothecin)
- Drug Class/Description
- Class: SN38
Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.
Target
- Introduction
- Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
- Alternative Names
- CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100;
- Gene ID
- 1048
- UniProt ID
- A0A024R0K5
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Datasheet
MSDS
COA
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| TAB-413LC-S(P) | Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-413LC-S(P)) | FC, ELISA | Human scFv |
| TAB-409LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-409LC-F(E)) | SPR, ELISA, FC | Humanized Fab |
| TAB-412LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-412LC-F(E)) | FC, ELISA | Chimeric (Mouse/Human) Fab |
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| TAB-411LC-S(P) | Human Anti-Human CEACAM5 Recombinant Antibody scFv Fragment | ELISA | Human antibody |
| TAB-411LC-F(E) | Human Anti-Human CEACAM5 Recombinant Antibody Fab Fragment | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
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| TAB-410LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-410LC-F(E)) | ELISA | Humanized Fab |
| TAB-414LC-F(E) | Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-414LC-F(E)) | FC, ELISA | Humanized Fab |
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| HPAB-0155-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P)) | Activ | Humanized scFv |
| HPAB-0243-FY-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody scFv Fragment (HPAB-0243-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0348-YJ-S(P) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); scFv Fragment | ELISA, IHC | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0155-FY-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E)) | Activ | Humanized Fab |
| HPAB-0243-FY-F(E) | Human Anti-CEACAM5 Recombinant Antibody Fab Fragment (HPAB-0243-FY-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| HPAB-0348-YJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-1094WJ-F(E) | Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E)) | ELISA, FC | Mouse Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-1071F | Mouse Anti-CEACAM5 Recombinant Antibody (clone PARLAM 4) | FC, ICC, IHC-Fr, IHC-P, WB | Mouse IgG1 |
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| VS3-CJ446 | Mouse Anti-CEACAM5 Recombinant Antibody (clone ABT-CEA) | IHC-P | Mouse IgG2b, κ |
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| CAT | Product Name | Application | Type |
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| VS-1024-XY62 | Mouse Anti-NHP CEACAM5 Recombinant Antibody (clone SPM506) | IHC, IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
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| VS-0125-FY29 | Human Anti-CEACAM5 (clone MFE-23) scFv-Fc Chimera | BI | Human IgG1, scFv-Fc |
| VS-0125-FY89 | Human Anti-CEACAM5 (clone A5B7) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS-0425-YC97 | Recombinant Anti-CEACAM5 Vesicular Antibody, EV Displayed (VS-0425-YC97) | ELISA, FC, Neut, Cell-uptake |
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| VS-0525-XY1355 | Anti-CEACAM5 Immunohistochemistry Kit | IHC | |
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