Is this antibody humanized?

Yes, this product (clone YC054) is a Humanized scFv fragment. It binds to Human FGF2 and is designed for potential use in tumor research due to its good tumor-targeting and tissue penetrating ability.

What application is this scFv validated for?

This recombinant antibody fragment is validated for use in Enzyme-linked Immunosorbent Assay (ELISA). It specifically recognizes bFGF (FGF2) and can be used to study its role in angiogenesis and tumor growth.

Human Anti-FGF2 Recombinant Antibody (clone YC054); scFv Fragment

CAT#: NS-009CN-S(P)

Recombinant monoclonal antibody to bFGF. This product is a humanized antibody that can be potentially used for the diagnose and treatment of tumor due to its good tumor-targeting and approved tumor tissue penetrating ability, as well as high blood clearance rate.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nuclear bodies.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/641_G7_4_selected.jpg

Normal Tissue Figure 2 IHC staining of human caudate

Immunohistochemical staining of human caudate shows nuclear positivity in glia.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/65502/1336_684_200x200.jpg

Subcellular Location Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & nuclear bodies.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/640_G7_1_red_green.jpg

Subcellular Location Figure 4 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nuclear bodies.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/642_G7_1_red_green.jpg

Normal Tissue Figure 5 Cerebral cortex

Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_B_9_5.jpg

Normal Tissue Figure 6 Caudate

Glial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_B_8_7.jpg

Normal Tissue Figure 7 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_A_8_3.jpg

Normal Tissue Figure 8 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/125/2074_A_9_5.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, hTERT-HME1)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138685-FGF2

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Specifications

Host Species
Human

Derivation
Humanized

Type
Humanized scFv

Specificity
Human FGF2

Species Reactivity
Human

Clone
YC054

Applications
ELISA

Related Disease
Tumor

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Fibroblast Growth Factor 2; Fibroblast Growth Factor 2 (Basic); Heparin-Binding Growth Factor 2; HBGF-2; FGF-2; BFGF; FGFB; Basic Fibroblast Growth Factor BFGF; Basic Fibroblast Growth Factor; Prostatropin

Gene ID
2247

UniProt ID
P09038

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Breast cancer biomarkers at key points during disease progression

Tumor Targeting Scfv

Clone YC054 is a remarkable humanized scFv fragment. We used it in ELISA and found it binds strongly to Human FGF2. Its properties, such as good tumor-targeting and tissue penetrating ability, make it an exciting tool for our research into tumor growth and angiogenesis.

High Clearance Rate

In our studies, we noted that this antibody fragment has a high blood clearance rate, which is beneficial for certain imaging applications. It specifically targets bFGF and has been instrumental in our work understanding the role of fibroblast growth factors in limb and nervous system development.

Q&As

Is this antibody humanized?

A: Yes, this product (clone YC054) is a Humanized scFv fragment. It binds to Human FGF2 and is designed for potential use in tumor research due to its good tumor-targeting and tissue penetrating ability.
What application is this scFv validated for?

A: This recombinant antibody fragment is validated for use in Enzyme-linked Immunosorbent Assay (ELISA). It specifically recognizes bFGF (FGF2) and can be used to study its role in angiogenesis and tumor growth.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - NS-009CN-S(P).pdf

MSDS

MSDS - NS-009CN-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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