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    FGF2

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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
    Protein class

    Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, RAS pathway related proteins, Transporters

    Predicted location

    Intracellular, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (Astrocytes, Fibroblasts, Oligodendrocyte precursor cells, Endometrial stromal cells, Adipocytes)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, hTERT-HME1)

    Interaction

    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).

    Molecular function

    Developmental protein, Growth factor, Heparin-binding, Mitogen

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