The antibody is used to bind the FGF receptor 4 (FGFR4) and the medical use thereof, in particular for the diagnosis prevention or treatment of diseases associated with FGFR expression, overexpression or hyperactivity.
Figure 1 Three examples of anti-FGFR4 antibodies bind specifically to FGFR4.
The binding of antibodies XPA.48.056, XPA.48.117, and XPA.48.148 was evaluated by measuring binding to CHO-hFGFR4 cells (Panel A); HepG2 (Panel B); and HuH7 cells (Panel C) by FACS.
Figure 2 Three examples of anti-FGFR4 antibodies are capable of neutralizing FGF-19 induced phosphorylation of intracellular proteins.
Each of the three example antibodies were able to neutralize pERK (FIG. 4, Panel A) and pGSK-3P (FIG. 4, Panel B) in the presence of a sub-maximal concentration of rfiFGF-19 as measured using electrochemiluminescence.
Figure 3 Three examples of anti-FGFR4 antibodies are capable of mediating antibody-dependent cellular cytotoxicity in HepG2 cells (Panel A), HuH-7 cells (Panel B) and HCT116-FGFR4 cells (Panel C).
Percent specific cytotoxicity was calculated using 1 or 10 mg/ml antibody.
Figure 4 Three examples of anti-FGFR4 antibodies are capable of binding to mouse FGFR4 in addition to human FGFR4.
Panel A shows dose-dependent binding of XPA.48.056, XPA.48.117, and XPA.48.148 to endogenous AML12 mouse hepatocytes as measured by flow cytometry. Panel B shows FACS binding of 50 nM XPA.48.056, XPA.48.117, and XPA.48.148 to HEK293E cells transiently transfected with mouse FGFR4 cDNA. Data was normalized to the degree of signal measured for untransfected cells.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-065WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-065WM) | ELISA, FC | Mouse IgG |
TAB-067WM | Anti-Human FGFR4 Recombinant Antibody (F85-6C5) | IP, ELISA | |
TAB-068WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-068WM) | ELISA, WB | Mouse IgG |
TAB-069WM | Rat Anti-FGFR4 Recombinant Antibody (TAB-069WM) | ELISA, WB, FC, Inhib | Rat IgG |
TAB-067WM-S(P) | Anti-Human FGFR4 Recombinant Antibody scFv Fragment (F85-6C5) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-066WM | Anti-Human FGFR4 Recombinant Antibody (XPA.48.056) | ELISA, FC | Human Antibody |
TAB-066WM-S(P) | Anti-Human FGFR4 Recombinant Antibody scFv Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
TAB-066WM-F(E) | Anti-Human FGFR4 Recombinant Antibody Fab Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
TAB-384CQ | Human Anti-FGFR4 Recombinant Antibody (TAB-384CQ) | ELISA | Human IgG |
TAB-384CQ-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-384CQ-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0739CT | Recombinant Mouse anti-Human FGFR4 Monoclonal antibody (NN0390-7I44) | WB | |
HPAB-0054-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0054-LS) | Inhib | Human IgG |
HPAB-0055-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0055-LS) | Inhib | Human IgG |
HPAB-0056-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0056-LS) | Inhib | Human IgG |
HPAB-0057-LS | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117) | Inhib, ELISA, WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1300 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone DS1300AB) | WB | Rabbit IgG |
MOR-4575 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone TH87DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0054-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0054-LS-S(P)) | Inhib | Human scFv |
HPAB-0055-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0055-LS-S(P)) | Inhib | Human scFv |
HPAB-0056-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0056-LS-S(P)) | Inhib | Human scFv |
HPAB-2922LY-S(P) | Mouse Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-2922LY-S(P)) | ELISA, FC | Mouse scFv |
HPAB-0442-FY-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0442-FY-S(P)) | Inhib | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0054-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0054-LS-F(E)) | Inhib | Human Fab |
HPAB-0055-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0055-LS-F(E)) | Inhib | Human Fab |
HPAB-0056-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0056-LS-F(E)) | Inhib | Human Fab |
HPAB-0057-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); Fab Fragment | Inhib, ELISA, WB | Human Fab |
HPAB-0058-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.148); Fab Fragment | Inhib, ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-028CN | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1) | ELISA, WB, FC, IHC, IP | Mouse IgG1 |
NS-028CN-F(E) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); Fab Fragment | ELISA, WB, FC, IHC, IP | Mouse Fab |
NS-028CN-S(P) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); scFv Fragment | ELISA, WB, FC, IHC, IP | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF433 | A*02:01/Human FGFR4 (ALLAGLVSL) MHC Pentamer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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