Human Anti-FGFR4 Recombinant Antibody (clone BM3)
CAT#: HPAB-0061-LS
The antibody is used to bind the FGF receptor 4 (FGFR4) and the medical use thereof, in particular for the diagnosis prevention or treatment of diseases associated with FGFR expression, overexpression or hyperactivity.
Published Data
Gene Expression
FC
Figure 1 Three examples of anti-FGFR4 antibodies bind specifically to FGFR4.
The binding of antibodies XPA.48.056, XPA.48.117, and XPA.48.148 was evaluated by measuring binding to CHO-hFGFR4 cells (Panel A); HepG2 (Panel B); and HuH7 cells (Panel C) by FACS.
Neut
Figure 2 Three examples of anti-FGFR4 antibodies are capable of neutralizing FGF-19 induced phosphorylation of intracellular proteins.
Each of the three example antibodies were able to neutralize pERK (FIG. 4, Panel A) and pGSK-3P (FIG. 4, Panel B) in the presence of a sub-maximal concentration of rfiFGF-19 as measured using electrochemiluminescence.
ADCC
Figure 3 Three examples of anti-FGFR4 antibodies are capable of mediating antibody-dependent cellular cytotoxicity in HepG2 cells (Panel A), HuH-7 cells (Panel B) and HCT116-FGFR4 cells (Panel C).
Percent specific cytotoxicity was calculated using 1 or 10 mg/ml antibody.
❮
❯
Normal Tissue
Figure 1 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27273/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human gall bladder
Immunohistochemical staining of human gall bladder shows strong cytoplasmic and membrane positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5196/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (CACO-2, Hep G2, RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160867-FGFR4
❮
❯
Specifications
- Immunogen
- FGFR4
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- Human FGFR4
- Species Reactivity
- Human
- Clone
- BM3
- Applications
- Inhib, ELISA, WB
- Related Disease
- Hepatocellular cancer, Breast cancer, Prostate cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, Neutralization, ADCC.
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for HPAB-0061-LS. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone BM3"
- CAT
- Product Name
See other products for "FGFR4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3383z | Mouse Anti-FGFR4 Recombinant Antibody (clone 31F7) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-065WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-065WM) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066WM | Anti-Human FGFR4 Recombinant Antibody (XPA.48.056) | ELISA, FC | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067WM | Anti-Human FGFR4 Recombinant Antibody (F85-6C5) | IP, ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-068WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-068WM) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-069WM | Rat Anti-FGFR4 Recombinant Antibody (TAB-069WM) | ELISA, WB, FC, Inhib | Rat IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-065WM-S(P) | Mouse Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-065WM-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066WM-S(P) | Anti-Human FGFR4 Recombinant Antibody scFv Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066WM-F(E) | Anti-Human FGFR4 Recombinant Antibody Fab Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-384CQ | Human Anti-FGFR4 Recombinant Antibody (TAB-384CQ) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-384CQ-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-384CQ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0739CT | Recombinant Mouse anti-Human FGFR4 Monoclonal antibody (NN0390-7I44) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1300 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone DS1300AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4575 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone TH87DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0054-LS) | Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0055-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0055-LS) | Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0056-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0056-LS) | Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0054-LS-S(P)) | Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0055-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0055-LS-S(P)) | Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0056-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0056-LS-S(P)) | Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0057-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); scFv Fragment | Inhib, ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0058-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.148); scFv Fragment | Inhib, ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0054-LS-F(E)) | Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0055-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0055-LS-F(E)) | Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0056-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0056-LS-F(E)) | Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0057-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); Fab Fragment | Inhib, ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0058-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.148); Fab Fragment | Inhib, ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-028CN | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1) | ELISA, WB, FC, IHC, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-028CN-F(E) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); Fab Fragment | ELISA, WB, FC, IHC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-028CN-S(P) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); scFv Fragment | ELISA, WB, FC, IHC, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY103 | AbPlus™ Anti-FGFR4 Magnetic Beads (F85-6C5) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC308 | Recombinant Anti-FGFR4 Vesicular Antibody, EV Displayed (VS-0425-YC308) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2545 | Anti-FGFR4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC134 | SmartAb™ Recombinant Anti-FGFR4 pH-dependent Antibody (Clone XPA.48.117) | Inhib, ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC51 | Anti-FGFR4 Antibody Prodrug, Protease Activated (VS-1025-YC51) | ISZ, Cyt, FuncS |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, IHC, FC, Cyt, ELISA
Application: ELISA, Neut, FuncS
Application: WB, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
