Human Anti-FGFR4 Recombinant Antibody (clone BM3) (CAT#: HPAB-0061-LS)
The antibody is used to bind the FGF receptor 4 (FGFR4) and the medical use thereof, in particular for the diagnosis prevention or treatment of diseases associated with FGFR expression, overexpression or hyperactivity.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
FC
Figure 1 Three examples of anti-FGFR4 antibodies bind specifically to FGFR4.
The binding of antibodies XPA.48.056, XPA.48.117, and XPA.48.148 was evaluated by measuring binding to CHO-hFGFR4 cells (Panel A); HepG2 (Panel B); and HuH7 cells (Panel C) by FACS.
Neut
Figure 2 Three examples of anti-FGFR4 antibodies are capable of neutralizing FGF-19 induced phosphorylation of intracellular proteins.
Each of the three example antibodies were able to neutralize pERK (FIG. 4, Panel A) and pGSK-3P (FIG. 4, Panel B) in the presence of a sub-maximal concentration of rfiFGF-19 as measured using electrochemiluminescence.
ADCC
Figure 3 Three examples of anti-FGFR4 antibodies are capable of mediating antibody-dependent cellular cytotoxicity in HepG2 cells (Panel A), HuH-7 cells (Panel B) and HCT116-FGFR4 cells (Panel C).
Percent specific cytotoxicity was calculated using 1 or 10 mg/ml antibody.
Specifications
- Immunogen
- FGFR4
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- Human FGFR4
- Species Reactivity
- Human
- Clone
- BM3
- Applications
- Inhib, ELISA, WB
- Related Disease
- Hepatocellular cancer, Breast cancer, Prostate cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, Neutralization, ADCC.
Target
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-065WM-S(P) | Mouse Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-065WM-S(P)) | ELISA, FC | Mouse scFv |
| TAB-067WM-S(P) | Anti-Human FGFR4 Recombinant Antibody scFv Fragment (F85-6C5) | ELISA | |
| TAB-068WM-S(P) | Mouse Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-068WM-S(P)) | ELISA, WB | Mouse scFv |
| TAB-069WM-S(P) | Rat Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-069WM-S(P)) | ELISA, WB, FC | Rat scFv |
| TAB-065WM-F(E) | Mouse Anti-FGFR4 Recombinant Antibody; Fab Fragment (TAB-065WM-F(E)) | ELISA, FC | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
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