Afuco™ Anti-Human GAD2 ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-284CL
Anti-GAD2 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. GAD65Ab are common in healthy individuals, but masked by epitope-specific anti-idiotypic antibodies. GAD65Ab may have a pathogenic role in the disease process in patients with Stiff Person Syndrome (SPS). GAD65Ab in SPS patients inhibit the enzyme's activity and result in a deficit in the major inhibitory neurotransmitter GABA, possibly causing clinical symptoms such as muscle spasms and stiffness.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_B_9_5.jpg
Normal Tissue
Figure 2 Pancreas
Pancreatic endocrine cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78177/163309_A_3_3.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136750-GAD2
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Diabetes Type 1
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
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Related Diseases
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "GAD2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1147z | Mouse Anti-GAD2 Recombinant Antibody (clone 28G2) | WB, ELISA, FC | Mouse IgG1 |
| MOB-0421ZL | Rabbit anti-GAD2 polyclonal Antibody | WB | |
| MOB-2430MZ | Recombinant Mouse Anti-Rat GAD2 Antibody (clone HBE-7) | IHC-FoFr, IHC-Fr, IHC-P, WB | Mouse antibody |
| MOB-131CQ | Mouse Anti-GAD2 Recombinant Antibody (clone YC068) | ELISA, ICC, IHC, FC, WB | Mouse IgG |
| HPAB-1982-FY | Human Anti-GAD2 Recombinant Antibody (clone b78) | Inhib | Human IgG1, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1389 | Hi-Affi™ Rabbit Anti-GAD2 Recombinant Antibody (clone DS1389AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1982-FY-F(E) | Human Anti-GAD2 Recombinant Antibody (clone b78); Fab Fragment | Inhib | Human Fab, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1982-FY-S(P) | Human Anti-GAD2 Recombinant Antibody (clone b78); scFv Fragment | Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF030 | DRB1*04:01/Human GAD65 (IAFTSEHSHFSLK) MHC Monomer | MHC Multimer | |
| MHC-YF033 | DRB1*04:01/Human GAD65 (NFIRMVISNPAAT) MHC Monomer | MHC Multimer | |
| MHC-YF034 | DRB1*04:01/Human GAD65 (DVMNILLQYVVKSFDRSTKV) MHC Monomer | MHC Multimer | |
| MHC-YF035 | DRB1*04:01/Human GAD65 (KGMAALPRLIAFTSEHSHFS) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC793 | AbPlus™ Anti-GAD2 Magnetic Beads (VS-0724-YC793) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2716 | Anti-GAD2 Immunohistochemistry Kit | IHC |
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