anti-GD2 immunotoxin 14G2a (IgG)-RTA
CAT#: AGTO-L018R
This immunotoxin was achieved by conjugating/fusing the Anti-GD2 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neuroblastoma cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of neuroblastoma.
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 14G2a
- Molecule Class
- L kappa; IgG2a-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Neuroblastoma
Target
- Alternative Names
- disialoganglioside; GD2; Neuroblastoma; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
Customer Review
There are currently no Customer reviews or questions for AGTO-L018R. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "Clone 14G2a"
- CAT
- Product Name
See other products for "GD2"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-731 | Anti-GD2 Recombinant Antibody (TAB-731) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-304CL | Anti-Human GD2 Recombinant Antibody (hu14.18K322A) | FC, FuncS | Antibody |
PABX-059 | Human Anti-GD2 Recombinant Antibody (PABX-059) | FuncS | IgG1, κ |
PABX-059-F (E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (PABX-059-F (E)) | FC, ELISA, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a) | ELISA, WB, FuncS | Mouse IgG |
PABL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8) | FC, ELISA, FuncS | Mouse IgG |
PABZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1) | WB, FuncS | Mouse IgG |
HPAB-1524WJ | Human Anti-GD2 Recombinant Antibody (clone KM8138) | ELISA, WB | Human IgG |
HPAB-1525WJ | Human Anti-GD2 Recombinant Antibody (clone KM1138) | ELISA, WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
PSBL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8); scFv Fragment | FC, ELISA, FuncS | Mouse scFv |
MOB-181CQ | Human Anti-GD2 Recombinant Antibody (MOB-181CQ) | ELISA, FC, FuncS | Humanized scFv |
HPAB-0701-CN-S(P) | Human Anti-GD2 Recombinant Antibody (clone AB527); scFv Fragment | ELISA, FC, IHC, IF | Human scFv |
HPAB-1524WJ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (clone KM8138) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1); Fab Fragment | WB, FuncS | Mouse Fab |
FAMAB-0126-YC-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); Fab Fragment | ELISA | Mouse Fab |
HPAB-0701-CN-F(E) | Human Anti-GD2 Recombinant Antibody (clone AB527); Fab Fragment | ELISA, FC, IHC, IF | Human Fab |
HPAB-0027-WJ-F(E) | Mouse Anti-GD2 Recombinant Antibody; Fab Fragment (HPAB-0027-WJ-F(E)) | ELISA, RIA | Mouse Fab |
HPAB-1030WJ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (HPAB-1030WJ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-075CQ | Human Anti-GD2 Recombinant Antibody (TAB-075CQ) | ELISA, FC | Human IgM, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-074CQ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (TAB-074CQ-S(P)) | ELISA, FC | Human scFv |
TAB-075CQ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (TAB-075CQ-S(P)) | ELISA, FC | Human scFv |
TAB-076CQ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (TAB-076CQ-S(P)) | ELISA, FC | Human scFv |
TAB-077CQ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (TAB-077CQ-S(P)) | ELISA, FC | Human scFv |
PABX-059-S (P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (PABX-059-S (P)) | FC, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-029CN | Mouse Anti-GD2 Recombinant Antibody (clone 5F11) | WB | Mouse IgG |
NS-030CN | Mouse Anti-GD2 Recombinant Antibody (clone 3G6) | WB | Mouse IgG |
NS-029CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); Fab Fragment | WB | Mouse Fab |
NS-030CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 3G6); Fab Fragment | WB | Mouse Fab |
NS-029CN-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); scFv Fragment | WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-731 | Afuco™ Anti-GD2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-731) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0125-FY63 | Human Anti-GD2 (clone 3F8) scFv-Fc Chimera | FC, ELISA, FuncS, ADCC, Cyt | Human IgG1, scFv-Fc |
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, ELISA
Application: WB, ELISA, FC, IHC, IP
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: IB, FC, ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.