Human Anti-GD2 (clone 3F8) scFv-Fc Chimera (CAT#: VS-0125-FY63)
This anti-GD2 scFv-Fc antibody specifically targets the GD2 antigen and can effectively bind to it on the surface of neuroblastoma cells, allowing for precise localization and targeting of cancer cells. Since GD2 is widely expressed in neuroblastoma cells, this antibody is expected to significantly enhance the efficacy of targeted therapies during treatment while minimizing effects on normal cells. By harnessing the power of the immune system, this antibody has the potential to improve patient outcomes and increase their survival rates.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 3F8
- Applications
- Flow Cytometry, ELISA, Functional Assay, Antibody-dependent cellular cytotoxicity, Cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This chimeric scFv-IgG Fc antibody has potential functions to elicit cytotoxic activity against the neuroblastoma cell line SH-SY5Y expressing GD2 through antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) mechanisms. Therefore, its potential functionality can be summarized as mediating anti-tumor activity by targeting and eliminating malignant cells through the utilization of human immune system cells.
Target
- Alternative Names
- Ganglioside GD2, GD2
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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