Mouse Anti-GD2 Recombinant Antibody (clone 7A4)
CAT#: FAMAB-0126YC
A antibody directed against GD2 (7A4) was cloned, sequenced, and expressed. Its binding properties were characterized and compared to that of the parental mab 7A4. The 7A4 bound to GD2+ neuroblastoma cell lines but not to GD2- cell lines or to GD2- cells isolated from peripheral blood. ELISA and thin-layer chromatography (TLC) indicated that it retained the anti-GD2 specificity, and exhibited a slight cross-reaction with GD3 as the parental mab. This antibody makes it possible to develop new useful reagents through genetic engineering for adjuvant tumor therapy.
Published Data
FC
Figure 1 Binding of the MAb 7A4.
Gd2+ LAN 1 neuroblastoma cells were incubated with either the parental Mab 74A (upper left panel) or the scFv 7A4 (lower left panel).
WB
Figure 2 Immunostaining of purified gangliosides on HPTLC plates by the scFv 7A4
After chromatography, purified gangliosides were immunostained with the Mab 7A4 or with the scFv 7A4.
ELISA
Figure 3 ELISA binding of scFv 7A4 to purified gangliosides.
Binding of various concentrations of MAb 7A4 or scFv 7A4 to purified GD2.
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG3, κ
- Specificity
- Human GD2
- Species Reactivity
- Human
- Clone
- 7A4
- Applications
- ELISA
- Related Disease
- Disseminated neuroblastoma
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- GD2; Disialoganglioside
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| PFBL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8); Fab Fragment | FC, ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
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| TAB-074CQ | Human Anti-GD2 Recombinant Antibody (TAB-074CQ) | ELISA, FC | Human IgG1, κ |
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| TAB-075CQ | Human Anti-GD2 Recombinant Antibody (TAB-075CQ) | ELISA, FC | Human IgM, κ |
| CAT | Product Name | Application | Type |
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| TAB-078CQ | Human Anti-GD2 Recombinant Antibody (TAB-078CQ) | ELISA, FC | Human IgG1, κ |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| PABX-059-F (E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (PABX-059-F (E)) | FC, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| NS-029CN | Mouse Anti-GD2 Recombinant Antibody (clone 5F11) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
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| NS-030CN | Mouse Anti-GD2 Recombinant Antibody (clone 3G6) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
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| NS-029CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); Fab Fragment | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-030CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 3G6); Fab Fragment | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-029CN-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); scFv Fragment | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0126-YC-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0126-YC-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); Fab Fragment | ELISA | Mouse Fab |
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