Anti-GD2 Antibody-Cytokine Fusion Protein, IgG (hu14.18)-IL2 (CAT#: ACFP-SH030)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The fusion protein retains its ability to activate IL2 responsive cells through the IL2 receptor and retains its ability to bind to GD2-positive tumor cells and to deliver IL2 to their surface. This immunocytokine was designed for treating neuroblastomas, medulloblastomas, astrocytomas, melanomas, small-cell lung cancer, osteosarcomas and other soft tissue sarcomas..
Specific Inquiry
Specifications
- Target
- GD2
- Molecule Class
- L Kappa; IgG1-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- hu14.18
- Related Disease
- Neuroblastomas, Medulloblastomas, astrocytomas, Melanomas, Small-cell lung cancer, Osteosarcomas and other soft tissue sarcomas.
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Disialoganglioside GD2; Ganglioside G2; GD2
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| NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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