Anti-GD2 Immunocytokine, IgG (hu14.18)-IL2 (ACFP-SH030)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The fusion protein retains its ability to activate IL2 responsive cells through the IL2 receptor and retains its ability to bind to GD2-positive tumor cells and to deliver IL2 to their surface. This immunocytokine was designed for treating neuroblastomas, medulloblastomas, astrocytomas, melanomas, small-cell lung cancer, osteosarcomas and other soft tissue sarcomas..
Specifications
- Target
- GD2
- Molecule Class
- L Kappa; IgG1-IL2
- Species Reactivity
- Human
- Host
- Humanized from Mouse
- Expression Host
- CHO
- Clone
- hu14.18
- Related Disease
- Neuroblastomas, Medulloblastomas, astrocytomas, Melanomas, Small-cell lung cancer, Osteosarcomas and other soft tissue sarcomas.
- Cytokines 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Disialoganglioside GD2; Ganglioside G2; GD2
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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