Recombinant Mouse Anti-HIV-1 Antibody (Fab28)
CAT#: PABX-093
Anti-HIV-1 antibody is a Mouse antibody of IgG class that binds to an HIV-1. This antibody binds to a portion of the surface of the p51 palm subdomain and has no contacts with either the p66 subunit or the dsDNA. The segment of p51 containing the Fab28 epitope corresponds to the b12-b13-b14 sheet of p66.
Published Data
Figure 1 Ribbon (Carson, 1987) diagram showing the overall structure of the HIV-1 RT/dsDNA/Fab28 complex.
The subdomains of the p66 and p51 subunits of HIV-1 RT are colored as follows: ®ngers, blue; palm, red; thumb, green; connection, yellow; and RNase H, orange. The bound dsDNA is shown with the template strand as a dark gray ribbon and the primer strand as a light gray ribbon; base-pairs are represented by bars. The monoclonal antibody fragment Fab28 is shown with the light chain in light gray and the heavy chain in dark gray.
Ding, J., Das, K., Hsiou, Y., Sarafianos, S. G., Clark Jr, A. D., Jacobo-Molina, A., ... & Arnold, E. (1998). Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 Å resolution. Journal of molecular biology, 284(4), 1095-1111.
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native HIV-1
- Species Reactivity
- Human immunodeficiency virus 1
- Clone
- Fab28
- Applications
- WB 1:1000-1:5000
1:3000-1:15000 ELISA
FuncS(assay-depended)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- HIV-1; human immunodeficiency virus
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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