Human Anti-HIV-1 Recombinant Antibody (clone 2G9) (CAT#: HPAB-1988-FY)

This product is a recombinant antibody that recognizes HIV-1. The monoclonal antibody 2G9 reacts with the epitope of HIV-1.


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Neut

Figure 1 Dependence of Ab neutralizing activity on duration of pretreatment with HIV while holding constant the exposure of PBMCs to Ab at all data points (4 d).

Figure 1 Dependence of Ab neutralizing activity on duration of pretreatment with HIV while holding constant the exposure of PBMCs to Ab at all data points (4 d).

IgM 2G9 to the CD4BDcore. Methods were as in (A). HIV was treated with IgM 2G9 (0.3 or 1.3 μg/ml) in 0.66% FBS for the indicated durations. (C) Control IgG 4B6 to phosphatidylserine.

Planque, S. A., Mitsuda, Y., Nishiyama, Y., Karle, S., Boivin, S., Salas, M., ... & Hanson, C. V. (2012). Antibodies to a superantigenic glycoprotein 120 epitope as the basis for developing an HIV vaccine. The Journal of Immunology, 189(11), 5367-5381.

Neut

Figure 2 CD4BD̶ᶜᵒʳᵉ-specific IgM induced by E-416–433 immunization.

Figure 2 CD4BD̶ᶜᵒʳᵉ-specific IgM induced by E-416–433 immunization.

Neutralization of CCR5-dependent HIV subtype A, B, C, and D strains by IgM 2G9.

Planque, S. A., Mitsuda, Y., Nishiyama, Y., Karle, S., Boivin, S., Salas, M., ... & Hanson, C. V. (2012). Antibodies to a superantigenic glycoprotein 120 epitope as the basis for developing an HIV vaccine. The Journal of Immunology, 189(11), 5367-5381.


Specifications

  • Host Species
  • Human
  • Type
  • Human IgM
  • Specificity
  • HIV-1
  • Species Reactivity
  • HIV
  • Clone
  • 2G9
  • Applications
  • FC, ELISA, Neut
  • Related Disease
  • HIV

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The HIV-1 antibody has been reported in applications of Flow Cytometry, Enzyme-linked Immunosorbent Assay, Neutralization.

Target

  • Alternative Names
  • HIV-1; Human immunodeficiency virus-1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Single-domain Antibody

CAT Product Name Application Type
NAB-1889-sdAb Recombinant Anti-HIV-1 VHH Single Domain Antibody WB, ICC, ChiP, FA, ELISA Llama VHH
PNBL-038 Recombinant Anti-HIV-1 C186 gp120 VHH Single Domain Antibody (A12) WB, FuncS Llama VHH

Humanized Antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G037E Anti-HIV-1 immunotoxin 3B3 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G037D Anti-HIV-1 immunotoxin 3B3 (scFv)-DT Cytotoxicity assay, Function study

Chimeric Antibody

CAT Product Name Application Type
PABX-093-S (P) Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab28) WB, ELISA, FuncS scFv

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4221 Rabbit Anti-HIV-1 Recombinant Antibody (clone SI300DS) ELISA, ICC, IF, FC Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-068 Afuco™ Anti-HIV-1 ADCC Recombinant Antibody (Suvizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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