Anti-HIV-1 immunotoxin 3B3 (scFv)-DT
CAT#: AGTO-G037D
This immunotoxin was achieved by conjugating/fusing the Anti-HIV-1 scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to infected cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of immunodeficiency virus type 1 (HIV-1) infection.
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 3B3
- Molecule Class
- scFv-DT
- Toxin Description
- Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- immunodeficiency virus type 1 (HIV-1) infection
Target
- Alternative Names
- HIV; human immunodeficiency virus; acquired immunodeficiency syndrome; AIDS; HIV-1; human immunodeficiency virus type 1; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB417
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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