Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab28) (CAT#: PABX-093-S (P))
Anti-HIV-1 antibody is a Mouse of scFv class that binds to an HIV-1. This antibody binds to a portion of the surface of the p51 palm subdomain and has no contacts with either the p66 subunit or the dsDNA. The segment of p51 containing the Fab28 epitope corresponds to the b12-b13-b14 sheet of p66.
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Figure 1 Ribbon (Carson, 1987) diagram showing the overall structure of the HIV-1 RT/dsDNA/Fab28 complex.
The subdomains of the p66 and p51 subunits of HIV-1 RT are colored as follows: ®ngers, blue; palm, red; thumb, green; connection, yellow; and RNase H, orange. The bound dsDNA is shown with the template strand as a dark gray ribbon and the primer strand as a light gray ribbon; base-pairs are represented by bars. The monoclonal antibody fragment Fab28 is shown with the light chain in light gray and the heavy chain in dark gray.
Ding, J., Das, K., Hsiou, Y., Sarafianos, S. G., Clark Jr, A. D., Jacobo-Molina, A., ... & Arnold, E. (1998). Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 Å resolution. Journal of molecular biology, 284(4), 1095-1111.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- scFv
- Specificity
- Tested positive against native Human EGFR
- Species Reactivity
- Human immunodeficiency virus 1
- Clone
- Fab28
- Applications
- WB 1:1000-1:5000
ELISA 1:3000-1:15000
FuncS(assay-depended)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- HIV-1; human immunodeficiency virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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|---|---|---|---|
| NAB-1889-sdAb | Recombinant Anti-HIV-1 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| PNBL-038 | Recombinant Anti-HIV-1 C186 gp120 VHH Single Domain Antibody (PNBL-038) | WB, FuncS | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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