Afuco™ Anti-Human HMGB1 ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-349CL
Anti-HMGB1 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This is a humanized anti-HMGB1 antibody that binds specifically to a sequence consisting of an eight-amino-acid residue (EEEDDDDE) at the C terminal of the HMGB1 protein, and that is effective in the treatment or prophylaxis of various inflammatory diseases related to said protein.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73663/2043_F12_32_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5873/617_A1_1_selected.jpg
Subcellular Location
Figure 3 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong nuclear positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3506/10525_B_4_4_selected.jpg
Subcellular Location
Figure 4 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows strong nuclear positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5873/ihc_selected.jpg
Subcellular Location
Figure 5 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5873/613_A1_1_red_green.jpg
Subcellular Location
Figure 6 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5873/610_A1_1_red_green.jpg
Normal Tissue
Figure 7 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3506/10525_B_8_5.jpg
Normal Tissue
Figure 8 Colon
Endocrine cells
Staining: High
Intensity: Strong
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3506/10525_A_9_3.jpg
Normal Tissue
Figure 9 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3506/10525_A_8_4.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3506/10525_A_7_5.jpg
Normal Tissue
Figure 11 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3506/10525_A_8_8.jpg
RNA Expression
Figure 12 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000189403-HMGB1
❮
❯
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Inflammatory Diseases
Product Property
- Purity
- 95% by HPLC
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- HMGB1; high mobility group box 1; HMG1; HMG3; SBP-1; high mobility group protein B1; HMG-1; Amphoterin; high-mobility group box 1; high mobility group protein 1; Sulfoglucuronyl carbohydrate binding protein; high-mobility group (nonhistone chromosomal) protein 1
- Gene ID
- 3146
- UniProt ID
- A0A024RDR0
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-956 | Human Anti-HMGB1 Recombinant Antibody (clone Giby-1-4) | ELISA, WB | Human IgG |
| MRO-0755-CN | Rabbit Anti-HMGB1 Recombinant Antibody (clone CBACN-279) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-CJ537 | Rabbit Anti-HMGB1 Recombinant Antibody (VS3-CJ537) | WB, ICC, IF, IHC, FC | Rabbit IgG |
| VS3-WK1655 | Recombinant Mouse Anti-HMGB1 Detection Antibody (clone 1G1) | ELISA | Mouse IgG2b |
| VS-0824-CJ6 | Human Anti-HMGB1 Recombinant Antibody (clone G16) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0315CL | Mouse Anti-HMGB1 Recombinant Antibody (TAB-0315CL) | IHC | Mouse IgG |
| TAB-0316CL | Mouse Anti-HMGB1 Recombinant Antibody (TAB-0316CL) | ELISA, Inhib, FuncS, WB | Mouse IgG |
| TAB-0317CL | Mouse Anti-HMGB1 Recombinant Antibody (TAB-0317CL) | ELISA, Inhib, FuncS, WB | Mouse IgG |
| TAB-0318CL | Mouse Anti-HMGB1 Recombinant Antibody (TAB-0318CL) | ELISA, Inhib, FuncS, WB | Mouse IgG |
| TAB-100CT-S(P) | Anti-Human HMG1 Recombinant Antibody scFv Fragment (TAB-100CT-S(P)) | IF, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-099CT | Human Anti-HMGB1 Recombinant Antibody (TAB-099CT) | IF, ELISA, IHC | Human IgG1, λ |
| TAB-099CT-S(P) | Human Anti-HMGB1 Recombinant Antibody; scFv Fragment (TAB-099CT-S(P)) | ELISA, FC, Block | Human scFv |
| TAB-099CT-F(E) | Human Anti-HMGB1 Recombinant Antibody; Fab Fragment (TAB-099CT-F(E)) | ELISA, FC, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-101CT | Anti-Human HMG1 Recombinant Antibody | ELISA, BL | Human antibody |
| TAB-101CT-S(P) | Anti-Human HMG1 Recombinant Antibody scFv Fragment | ELISA, BL | Human antibody |
| TAB-101CT-F(E) | Anti-Human HMG1 Recombinant Antibody Fab Fragment | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1633 | Rabbit Anti-HMGB1 Recombinant Antibody (clone DS1633AB) | WB, IHC-P, FC | Rabbit IgG |
| MOR-0049-FY | Rabbit Anti-HMGB1 Recombinant Antibody (clone AFY0020) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2082 | PE-B*07:02/Human HMGB1 (APKRPPSAF) MHC Tetramer | FCM | |
| MHC-LC2083 | APC-B*07:02/Human HMGB1 (APKRPPSAF) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-FY-S(P) | Mouse Anti-HMGB1 Recombinant Antibody (clone 3E8); scFv Fragment | ELISA | Mouse scFv |
| HPAB-N0137-YC-S(P) | Mouse Anti-HMGB1 Recombinant Antibody; scFv Fragment (HPAB-N0137-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0101-WJ-S(P) | Human Anti-HMGB1 Recombinant Antibody; scFv Fragment (HPAB-0101-WJ-S(P)) | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0215-FY-F(E) | Mouse Anti-HMGB1 Recombinant Antibody (clone 3E8); Fab Fragment | ELISA | Mouse Fab |
| HPAB-N0137-YC-F(E) | Mouse Anti-HMGB1 Recombinant Antibody; Fab Fragment (HPAB-N0137-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-0101-WJ-F(E) | Human Anti-HMGB1 Recombinant Antibody; Fab Fragment (HPAB-0101-WJ-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1654 | Recombinant Mouse Anti-HMGB1 Capture Antibody (clone 1B5) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC699 | AbPlus™ Anti-HMGB1 Magnetic Beads (VS-0724-YC699) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1033 | Anti-HMGB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3204 | Anti-Mouse HMGB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3206 | Anti-Human HMGB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3205 | Anti-Rat HMGB1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC535 | CytoStream™ Rabbit Anti-HMGB1 Recombinant Antibody (VS13-YC535) | WB, ICC, IF, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC143 | Recombinant Anti-HMGB1 Eliminating Antibody, pH-Sensitive (VS-0625-YC143) | Antigen-Sweeping In Vivo. | Human IgG1 lambda |
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