Recombinant Humanized antibody to Human CSF1R
Figure 1 CSF-1R blockade increases the expression of intratumoural type I IFN signalling in patients with cancer treated with emactuzumab and is essential for the therapeutic synergy of cisplatin + anti-CSF-1R in the KEP mouse model a, Kaplan–Meier tumour-specific survival curves of KEP mice treated with cisplatin + control Ab, cisplatin + anti-CSF-1R, cisplatin + anti-IFNAR1 (n = 15 animals) or cisplatin + anti-CSF-1R + anti-IFNAR1 (n = 21 animals).
Cisplatin + anti-CSF-1R versus cisplatin + anti-CSF-1R + anti-IFNAR1: P = 0.0064 (two-tailed log-rank test). b, log2 ratio of intratumoural expression levels of 28 type I ISGs in emactuzumab (anti-CSF-1R)-treated patients (n = 31 patients) normalized against the pre-treatment expression levels. c, Box plots of the expression level of the 11 statistically significant upregulated type I ISGs in tumours of emactuzumab-treated patients (data from b, indicated by asterisks). Expression levels in the pre-treatment (baseline) tumour biopsies are compared to on-treatment (emactuzumab) biopsies. The top-most line is the maximum, the top of the box is the third quartile, the centre line is the median, the bottom of the box is the first quartile and the bottom-most line is the minimum. RPKM, reads per kilobase of exon per million mapped reads. The P values were determined by a two-tailed Student's t-test.
Salvagno, C., Ciampricotti, M., Tuit, S., Hau, C. S., Coffelt, S. B., Kersten, K.,... & Ooi, C. H. (2019). Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature cell biology.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-CSF1R ADCC Recombinant Antibody (Emactuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized antibody to Human CSF1R.
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-178CL | Afuco™ Anti-CSF1R Recombinant Antibody (AFC-178CL), ADCC Enhanced | ELISA, WB | Human IgG1 |
AFC-TAB-H23 | Afuco™ Anti-CSF1R ADCC Recombinant Antibody (Emactuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-011ML | Afuco™ Anti-CSF1R ADCC Recombinant Antibody (Cabiralizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-055 | Human Anti-CSF1R Recombinant Antibody (clone RG7155); Fab Fragment | FC, FuncS | Mouse Fab |
HPAB-0073-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0073-LS-F(E)) | Block | Mouse Fab |
HPAB-0074-LS-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0074-LS-F(E)) | Block | Human Fab |
HPAB-0075-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0075-LS-F(E)) | ELISA, Inhib | Mouse Fab |
HPAB-0076-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0076-LS-F(E)) | ELISA, Inhib | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-076MZ | Human Anti-CSF1R Recombinant Antibody (TAB-076MZ) | WB | Human IgG4 |
TAB-078MZ | Human Anti-CSF1R Recombinant Antibody (TAB-078MZ) | ELISA | Humanized IgG |
TAB-076MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-076MZ-S(P)) | WB | Human scFv |
TAB-078MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-078MZ-S(P)) | ELISA | Humanized scFv |
TAB-076MZ-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-076MZ-F(E)) | WB | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-077MZ | Mouse Anti-CSF1R Recombinant Antibody (TAB-077MZ) | ELISA | Mouse IgG2a, κ |
TAB-079MZ | Anti-Mouse CSF1R Recombinant Antibody (AFS98) | FC | |
TAB-077MZ-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-077MZ-S(P)) | ELISA | Mouse scFv |
TAB-077MZ-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-077MZ-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-508CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL141) | Neut, WB | Mouse IgG1 |
NEUT-509CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL809) | WB, Neut | Mouse IgG1 |
NEUT-510CQ | Mouse Anti-CSF1R Recombinant Antibody (clone MM0467-5V36) | WB, Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0825 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone DS825AB) | ELISA | Rabbit IgG |
MOR-4112 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone SI183DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0574-CN-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0574-CN-S(P)) | ELISA, Block | Mouse scFv |
HPAB-0575-CN-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0575-CN-S(P)) | ELISA, Block | Mouse scFv |
HPAB-0576-CN-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0576-CN-S(P)) | ELISA, Block | Humanized scFv |
HPAB-0577-CN-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0577-CN-S(P)) | ELISA, FC | Mouse scFv |
HPAB-0579-CN-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0579-CN-S(P)) | ELISA, FC, Neut | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0177-FY | Human Anti-CSF1R Recombinant Antibody (HPAB-0177-FY) | Block | Human IgG |
HPAB-J0060-YC | Human Anti-CSF1R Recombinant Antibody (HPAB-J0060-YC) | ELISA, Block, ADCC | Human IgG |
HPAB-J0061-YC | Human Anti-CSF1R Recombinant Antibody (HPAB-J0061-YC) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Chimeric (mouse/human) IgG1 |
HPAB-J0062-YC | Human Anti-CSF1R Recombinant Antibody (HPAB-J0062-YC) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized IgG |
HPAB-J0063-YC | Human Anti-CSF1R Recombinant Antibody (HPAB-J0063-YC) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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