Anti-human IL23A Recombinant Antibody (E11E7) (TAB-606LC)

Name: Anti-human IL23A Recombinant Antibody (E11E7) (TAB-606LC)
SKU: TAB-606LC
Rating: 5 (1 reviews)

CAT#: TAB-606LC

Recombinant monoclonal antibody E11E7 is a rat monoclonal antibody that specifically binds to human IL-23. Binding of the antibody to IL-23 as measured by SPR and the K_d value is 0.1 nM. It inhibits the binding of IL-23 to IL-23R. It also can be potentially used in the research of psoriasis, Crohn's disease and multiple sclerosis.

Published Data Gene Expression

Neut

Figure 1 A graphical representation showing E11E7 or E11E7Chimera-mediated neutralization of IL-23-induced IL-17 secretion by mouse splenocytes.

Values are expressed as percentage inhibition compared to IL-23-induced IL-17 secretion by mouse splenocytes in the absence of antibody.

ELISA

Figure 2 Graphical representations showing detection of recombinant IL-23 using E11E7 as a capture antibody as performed via ELISA (A) and the detection of native IL-23, by E11E7, produced by the cell line THP-1 when stimulated with Pokeweed Mitogen (PWM) and lipopolysaccharide (LPS), as measured by ELISA (B).

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Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/if_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells in and outside germinal center.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_8_selected.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/60_H7_1_blue_red_green.jpg

Normal Tissue Figure 4 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_9_3.jpg

Normal Tissue Figure 5 Testis

Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_6.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_8_8.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, U-266/70, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110944-IL23A

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Specifications

Immunogen
Plasmids allow the secretion of soluble IL-23

Host Species
Rat

Specificity
Human

Clone
E11E7

Applications
ELISA, Neut

Related Disease
Psoriasis, Crohn's disease and multiple sclerosis

Applications

Application Notes
This antibody has been tested for use in Enzyme-Linked Immunosorbent Assay and Neutralization.

Target

Alternative Names
IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor

Gene ID
51561

UniProt ID
Q9NPF7

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-606LC.pdf

MSDS

MSDS - TAB-606LC.pdf

COA

Certificate of Analysis Lookup

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CAT
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HPAB-1232-FY	Human Anti-IL23A Recombinant Antibody (HPAB-1232-FY)	ELISA	Human IgG
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CAT	Product Name	Application	Type
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HPAB-0518-CN-F(E)	Human Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0518-CN-F(E))	ELISA, FC	Humanized Fab
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HPAB-AP119-YC-S(P)	Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP119-YC-S(P))	ELISA	Mouse scFv
HPAB-AP120-YC-S(P)	Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP120-YC-S(P))	ELISA	Mouse scFv
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CAT	Product Name	Application	Type
TAB-607LC	Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC)	ELISA, Neut, FuncS	Chimeric antibody (rat/human)
TAB-607LC-S(P)	Anti-human IL23A scFv Fragment (E11E7Chimera)	ELISA	Chimeric antibody (rat/human)
TAB-607LC-F(E)	Anti-human IL23A Fab Fragment (E11E7Chimera)	ELISA	Chimeric antibody (rat/human)

CAT	Product Name	Application	Type
TAB-605LC-S(P)	Anti-human IL23A scFv Fragment (FM303)	ELISA	Humanized antibody
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CAT	Product Name	Application	Type
TAB-606LC-S(P)	Anti-human IL23A scFv Fragment (E11E7)	ELISA
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TAB-606LC-F(E)	Anti-human IL23A Fab Fragment (E11E7)	ELISA

CAT	Product Name	Application	Type
NEUT-1335CQ	Mouse Anti-IL23A Recombinant Antibody (NEUT-1335CQ)	FuncS, Neut	Mouse IgG1, κ
NEUT-1336CQ	Rabbit Anti-IL23A Recombinant Antibody (VMC198)	WB, Neut	Rabbit IgG2b
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CAT	Product Name	Application	Type
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