Afuco™ Anti-IL23A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-008ML)
CAT#: AFC-TAB-008ML
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL23A. It is a human monoclonal antibody that can be potentially used in the treatment of Crohn's disease (CD).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells in and outside germinal center.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_8_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/60_H7_1_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_8_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110944-IL23A
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Specificity
- Human IL23A
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, Inhib
- Conjugate
- Unconjugated
- Generic Name
- Brazikumab
- Related Disease
- Crohn's disease (CD)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Brazikumab"
Anti-Human IL23A Recombinant Antibody (Brazikumab)Recombinant monoclonal antibody to IL23A. Brazikumab is a human monoclonal antibody that can be potentially used in the treatment of Crohn's disease (CD).
See other products for "IL23A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1953-VHH | Recombinant Anti-human IL23A VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| TAB-005LC-VHH | Anti-human IL23A Recombinant Antibody (TAB-005LC-VHH) | ELISA | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-875 | Anti-Human IL23 Recombinant Antibody (Tildrakizumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| TAB-605LC | Anti-human IL23A Recombinant Antibody (FM303) (TAB-605LC) | ELISA | Humanized antibody |
| TAB-608LC | Anti-human IL23A Recombinant Antibody (21-4) (TAB-608LC) | ELISA | Humanized antibody |
| TAB-609LC | Anti-human IL23A Recombinant Antibody (8-22) (TAB-609LC) | ELISA | Humanized antibody |
| TAB-610LC | Anti-human IL23A Recombinant Antibody (6-22) (TAB-610LC) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-420CL | Anti-Human IL23A Recombinant Antibody (TAB-420CL) | FuncS | Antibody |
| TAB-613LC | Anti-human IL23A Recombinant Antibody (ST883/885) (TAB-613LC) | ELISA | Human antibody |
| TAB-622LC | Human Anti-IL23A Recombinant Antibody (TAB-622LC) | ELISA | Human antibody |
| TAB-613LC-S(P) | Anti-human IL23A scFv Fragment (ST883/885) | ELISA | Human antibody |
| TAB-622LC-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (TAB-622LC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-241 | Human Anti-IL23A Recombinant Antibody (clone CNTO1959); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0517-CN-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0517-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0518-CN-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0518-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0860-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0860-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-0861-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0861-FY-S(P)) | Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-606LC | Anti-human IL23A Recombinant Antibody (E11E7) (TAB-606LC) | ELISA, Neut | |
| TAB-614LC | Anti-human IL23A Recombinant Antibody (8C9) (TAB-614LC) | ELISA, Inhib | |
| TAB-615LC | Anti-human IL23A Recombinant Antibody (2H6) (TAB-615LC) | ELISA, Inhib | |
| TAB-621LC | Mouse Anti-IL23A Recombinant Antibody (TAB-621LC) | ELISA, WB, Neut | Mouse IgG |
| TAB-606LC-S(P) | Anti-human IL23A scFv Fragment (E11E7) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-607LC | Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) | ELISA, Neut, FuncS | Chimeric antibody (rat/human) |
| TAB-607LC-S(P) | Anti-human IL23A scFv Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
| TAB-607LC-F(E) | Anti-human IL23A Fab Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0967CT | Recombinant Mouse anti-Human IL23A Monoclonal antibody (IMU3847) | IHC-P, IP, WB | |
| HPAB-AP118-YC | Mouse Anti-IL23A Recombinant Antibody (HPAB-AP118-YC) | ELISA | Mouse IgG |
| HPAB-AP119-YC | Mouse Anti-IL23A Recombinant Antibody (HPAB-AP119-YC) | ELISA | Mouse IgG |
| HPAB-AP120-YC | Mouse Anti-IL23A Recombinant Antibody (HPAB-AP120-YC) | ELISA | Mouse IgG |
| HPAB-AP122-YC | Human Anti-IL23A Recombinant Antibody (HPAB-AP122-YC) | ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1335CQ | Mouse Anti-IL23A Recombinant Antibody (NEUT-1335CQ) | FuncS, Neut | Mouse IgG1, κ |
| NEUT-1336CQ | Rabbit Anti-IL23A Recombinant Antibody (VMC198) | WB, Neut | Rabbit IgG2b |
| NEUT-1337CQ | Human Anti-IL23A Recombinant Antibody (clone CBL1018) | Neut | Human IgG1, κ |
| NEUT-1338CQ | Mouse Anti-IL23A Recombinant Antibody (NEUT-1338CQ) | Neut | Mouse IgG1 |
| NEUT-1339CQ | Mouse Anti-Il23a Recombinant Antibody (clone CBL1028) | Neut | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4335 | Rabbit Anti-IL23A Recombinant Antibody (clone SI424DS) | ELISA | Rabbit IgG |
| MOR-4615 | Rabbit Anti-IL23A Recombinant Antibody (clone TH128DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0516-CN-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0516-CN-S(P)) | ELISA, FC, Neut | Human scFv |
| HPAB-0517-CN-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0517-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0518-CN-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0518-CN-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-AP118-YC-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP118-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-AP119-YC-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP119-YC-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-875 | Afuco™ Anti-IL23A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-875) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-620LC | Afuco™ Anti-IL23A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-620LC) | ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1120 | Anti-IL23A Immunohistochemistry Kit | IHC | |
| VS-0525-XY3514 | Anti-Human IL23A Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY128 | Human Anti-IL23A (clone AMG 139) scFv-Fc Chimera | Inhib, ELISA, FC | Human IgG1, scFv-Fc |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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