Afuco™ Anti-IL23A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-875)
CAT#: AFC-TAB-875
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human IL23. It is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells in and outside germinal center.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_8_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/60_H7_1_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_8_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110944-IL23A
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC
- Conjugate
- Unconjugated
- Generic Name
- Tildrakizumab
- Related Disease
- Psoriasis
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Tildrakizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tildrakizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Tildrakizumab"
Anti-Human IL23 Recombinant Antibody (Tildrakizumab)Recombinant humanized (from mouse) antibody expressed in CHO binding to human IL23. Tildrakizumab is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.
DrugMonitor™ Anti-Tildrakizumab Antibody (VS-1224-YC1200)Tildrakizumab is an interleukin-23 antagonist used to treat moderate to severe plaque psoriasis. The DrugMonitor™ Anti-Tildrakizumab Antibody (VS-1224-YC1200) is an anti-drug antibody (ADA) against Tildrakizumab. This drug-based antibody is raised in mice immunized with the Tildrakizumab. The anti-Tildrakizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Tildrakizumab in samples.
See other products for "IL23A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1953-VHH | Recombinant Anti-human IL23A VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
| TAB-005LC-VHH | Anti-human IL23A Recombinant Antibody (TAB-005LC-VHH) | ELISA | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-420CL | Anti-Human IL23A Recombinant Antibody (TAB-420CL) | FuncS | Antibody |
| TAB-613LC | Anti-human IL23A Recombinant Antibody (ST883/885) (TAB-613LC) | ELISA | Human antibody |
| TAB-622LC | Human Anti-IL23A Recombinant Antibody (TAB-622LC) | ELISA | Human antibody |
| TAB-613LC-S(P) | Anti-human IL23A scFv Fragment (ST883/885) | ELISA | Human antibody |
| TAB-008ML | Anti-Human IL23A Recombinant Antibody (Brazikumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG2, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-241 | Human Anti-IL23A Recombinant Antibody (clone CNTO1959) | WB, ELISA, FuncS | Human IgG |
| HPAB-0516-CN | Human Anti-IL23A Recombinant Antibody (HPAB-0516-CN) | ELISA, FC, Neut | Human IgG4, κ |
| HPAB-0517-CN | Mouse Anti-IL23A Recombinant Antibody (HPAB-0517-CN) | ELISA, FC | Mouse IgG |
| HPAB-0518-CN | Human Anti-IL23A Recombinant Antibody (HPAB-0518-CN) | ELISA, FC | Humanized IgG |
| ZG-0008U | Rabbit Anti-IL23A Recombinant Antibody (clone 1F6) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-241 | Human Anti-IL23A Recombinant Antibody (clone CNTO1959); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0516-CN-F(E) | Human Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0516-CN-F(E)) | ELISA, FC, Neut | Human Fab |
| HPAB-0860-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0860-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-0861-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0861-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-1751-FY-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-1751-FY-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605LC | Anti-human IL23A Recombinant Antibody (FM303) (TAB-605LC) | ELISA | Humanized antibody |
| TAB-608LC | Anti-human IL23A Recombinant Antibody (21-4) (TAB-608LC) | ELISA | Humanized antibody |
| TAB-609LC | Anti-human IL23A Recombinant Antibody (8-22) (TAB-609LC) | ELISA | Humanized antibody |
| TAB-610LC | Anti-human IL23A Recombinant Antibody (6-22) (TAB-610LC) | ELISA | Humanized antibody |
| TAB-611LC | Anti-human IL23A Recombinant Antibody (1-4) (TAB-611LC) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-606LC | Anti-human IL23A Recombinant Antibody (E11E7) (TAB-606LC) | ELISA, Neut | |
| TAB-614LC | Anti-human IL23A Recombinant Antibody (8C9) (TAB-614LC) | ELISA, Inhib | |
| TAB-615LC | Anti-human IL23A Recombinant Antibody (2H6) (TAB-615LC) | ELISA, Inhib | |
| TAB-621LC | Mouse Anti-IL23A Recombinant Antibody (TAB-621LC) | ELISA, WB, Neut | Mouse IgG |
| TAB-606LC-S(P) | Anti-human IL23A scFv Fragment (E11E7) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-607LC | Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) | ELISA, Neut, FuncS | Chimeric antibody (rat/human) |
| TAB-607LC-S(P) | Anti-human IL23A scFv Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
| TAB-607LC-F(E) | Anti-human IL23A Fab Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1335CQ | Mouse Anti-IL23A Recombinant Antibody (NEUT-1335CQ) | FuncS, Neut | Mouse IgG1, κ |
| NEUT-1336CQ | Rabbit Anti-IL23A Recombinant Antibody (VMC198) | WB, Neut | Rabbit IgG2b |
| NEUT-1337CQ | Human Anti-IL23A Recombinant Antibody (clone CBL1018) | Neut | Human IgG1, κ |
| NEUT-1338CQ | Mouse Anti-IL23A Recombinant Antibody (NEUT-1338CQ) | Neut | Mouse IgG1 |
| NEUT-1339CQ | Mouse Anti-Il23a Recombinant Antibody (clone CBL1028) | Neut | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4335 | Rabbit Anti-IL23A Recombinant Antibody (clone SI424DS) | ELISA | Rabbit IgG |
| MOR-4615 | Rabbit Anti-IL23A Recombinant Antibody (clone TH128DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-620LC | Afuco™ Anti-IL23A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-620LC) | ELISA | ADCC enhanced antibody |
| AFC-TAB-008ML | Afuco™ Anti-IL23A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-008ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP118-YC-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP118-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-AP119-YC-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP119-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-AP120-YC-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP120-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-AP122-YC-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP122-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-AP123-YC-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-AP123-YC-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1120 | Anti-IL23A Immunohistochemistry Kit | IHC | |
| VS-0525-XY3514 | Anti-Human IL23A Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY128 | Human Anti-IL23A (clone AMG 139) scFv-Fc Chimera | Inhib, ELISA, FC | Human IgG1, scFv-Fc |
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