Human Anti-IL23A (clone AMG 139) scFv-Fc Chimera

Name: Human Anti-IL23A (clone AMG 139) scFv-Fc Chimera
SKU: VS-0425-FY128
Rating: 5 (1 reviews)

CAT#: VS-0425-FY128

The anti-IL23A scFv-FC is a novel therapeutic construct that targets interleukin-23 subunit A (IL-23A), a key player in inflammatory diseases, particularly psoriasis and inflammatory bowel disease, by preventing its interaction with the IL-23 receptor, thus aiming to disrupt pro-inflammatory signaling.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/if_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in subsets of lymphoid cells in and outside germinal center.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_8_selected.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/60_H7_1_blue_red_green.jpg

Normal Tissue Figure 4 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_9_3.jpg

Normal Tissue Figure 5 Testis

Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_5_6.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1554/4856_A_8_8.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, U-266/70, U-266/84)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000110944-IL23A

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Specifications

Host Species
Human

Type
Human IgG1, scFv-Fc

Antibody Isotype
scFv-Fc

Specificity
AMG 139 is a human antibody that specifically recognizes the native human IL-23 heterodimer, with no significant binding to the human IL-12 heterodimer.

Species Reactivity
Human

Clone
AMG 139

Applications
Inhibition, ELISA, Flow Cytometry

Related Disease
Crohn's disease

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
The optimal dilution concentration is determined by the experiment.

Target

Alternative Names
Interleukin 23 Subunit Alpha

Gene ID
51561

UniProt ID
Q9NPF7

Long Name
Interleukin 23 Subunit Alpha

Sequence Similarities
Belongs to the IL-6 superfamily.

Cellular Localization
Secreted

Protein Refseq
NP_057668.1

Function
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity.
Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4.
This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A.
In turn, participates in the early and effective intracellular bacterial clearance.
Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0425-FY128.pdf

MSDS

MSDS - VS-0425-FY128.pdf

COA

Certificate of Analysis Lookup

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