Human Anti-IL23A (clone AMG 139) scFv-Fc Chimera (CAT#: VS-0425-FY128)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• AMG 139 is a human antibody that specifically recognizes the native human IL-23 heterodimer, with no significant binding to the human IL-12 heterodimer.

• Species Reactivity
• Human

• Clone
• AMG 139

• Applications
• Inhibition, ELISA, Flow Cytometry

• Related Disease
• Crohn's disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Interleukin 23 Subunit Alpha

• Gene ID
• 51561

• UniProt ID
• Q9NPF7

• Long Name
• Interleukin 23 Subunit Alpha

• Sequence Similarities
• Belongs to the IL-6 superfamily.

• Cellular Localization
• Secreted

• Protein Refseq
• NP_057668.1

• Function
• Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity.
  Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4.
  This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A.
  In turn, participates in the early and effective intracellular bacterial clearance.
  Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

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