anti-ITGA4 immunotoxin 15A8 (IgG)-Gel (CAT#: AGTO-L029G)
This immunotoxin was achieved by conjugating/fusing the Anti-ITGA4 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to breast cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of breast cancer.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74961/1608_C10_1_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74961/1608_C10_1_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (fHDF/TERT166, HEL, JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115232-ITGA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115232-ITGA4
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 15A8
- Molecule Class
- IgG-Gel
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Breast cancer
Target
- Alternative Names
- 269C wild type; Alpha 4 subunit of VLA 4 receptor; Antigen CD49D; Antigen CD49D, alpha 4 subunit of VLA 4 receptor; CD 49d; CD49 antigen like family member D; CD49 antigen-like family member D; CD49d; CD49d antigen; CDw49d; IA4; Integrin alpha 4; Integrin alpha 4 subunit; Integrin alpha IV; Integrin alpha-4; Integrin alpha-IV; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor); ITA4_HUMAN; ITGA 4; ITGA4; LPAM23; MGC90518; OTTHUMP00000205320; Very Late Activation Antigen 4; Very Late Activation Protein 4 Receptor Alpha 4 Subunit; Very late activation protein 4 receptor, alpha 4 subunit; VLA 4; VLA 4 subunit alpha; VLA-4 subunit alpha; VLA4; Breast cancer; Gelonin; Gel
- Gene ID
- 3676
- UniProt ID
- Q6PJE7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "ITGA4"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-135 | Anti-Human Integrin alpha 4 beta 7 Recombinant Antibody (Etrolizumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-360 | Human Anti-ITGA4 Recombinant Antibody (clone HP1/2) | FC, ELISA, FuncS | Human IgG |
| FN-044CQ | Recombinant Mouse Anti-ITGA4 Antibody (BU49) | FC, Block | Mouse IgG1 |
| HPAB-0466-YJ | Human Anti-ITGA4 Recombinant Antibody (clone IN9A) | ELISA, FC, Block | Human IgG1 |
| VS3-QX606 | Mouse Anti-ITGA4 Recombinant Antibody (clone 5C4) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-XY898 | Mouse Anti-ITGA4 Recombinant Antibody, FITC (clone 4ABU49) | FC, IF | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-360 | Human Anti-ITGA4 Recombinant Antibody (clone HP1/2); scFv Fragment | FC, ELISA, FuncS | Human scFv |
| HPAB-0466-YJ-S(P) | Human Anti-ITGA4 Recombinant Antibody (clone IN9A); scFv Fragment | ELISA, FC, Block | Human scFv |
| HPAB-1588WJ-S(P) | Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone TA2) | ELISA, WB | Mouse scFv |
| HPAB-1620WJ-S(P) | Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone HP1 / 2) | ELISA, WB | Mouse scFv |
| HPAB-1621WJ-S(P) | Human Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone huHP1 / 2) | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-249 | Human Anti-ITGA4 Recombinant Antibody (clone MAb 21.6); Fab Fragment | Neut, FuncS | Human Fab |
| HPAB-0466-YJ-F(E) | Human Anti-ITGA4 Recombinant Antibody (clone IN9A); Fab Fragment | ELISA, FC, Block | Human Fab |
| HPAB-1588WJ-F(E) | Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone TA2) | ELISA, WB | Mouse Fab |
| HPAB-1620WJ-F(E) | Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone HP1 / 2) | ELISA, WB | Mouse Fab |
| HPAB-1621WJ-F(E) | Human Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone huHP1 / 2) | ELISA, WB | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-717LC | Anti-human ITGA4 Recombinant Antibody (IN 10) (TAB-717LC) | ELISA | Human antibody |
| TAB-717LC-S(P) | Anti-human ITGA4 scFv Fragment (IN 10) | ELISA | Human antibody |
| TAB-717LC-F(E) | Anti-human ITGA4 Fab Fragment (IN 10) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-122 | Recombinant Mouse Anti-Integrin alpha 4 Antibody (ACT-1) | Neut, FuncS | IgG |
| PABX-122-S (P) | Recombinant Mouse Anti-Integrin alpha 4 Antibody scFv Fragment (ACT-1) | Neut, FuncS | scFv |
| PABX-122-F (E) | Recombinant Mouse Anti-Integrin alpha 4 Antibody Fab Fragment (ACT-1) | Neut, FuncS | Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1549CQ | Recombinant Mouse Anti-ITGA4 Antibody (2B4) | BL | IgG1 |
| NEUT-1550CQ | Recombinant Rat Anti-Itga4 Antibody (9C10(MFR4.B)) | FC, BL, IHC | IgG2a, κ |
| NEUT-1551CQ | Recombinant Rat Anti-Itga4 Antibody (R1-2) | FC, IP, BL, IHC | IgG2b, κ |
| NEUT-1552CQ | Recombinant Rat Anti-Itga4 Antibody (PS/2) | FC, BL | IgG2b |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1553CQ | Recombinant Rat Anti-Itga4 Antibody (CBL914) | FC, Neut | IgG2a, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1873 | Hi-Affi™ Recombinant Rabbit Anti-ITGA4 Monoclonal Antibody (DS1873AB) | ICC/IF, IHC-P, IP, WB | IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-135 | Afuco™ Anti-ITGA4 ADCC Recombinant Antibody (Etrolizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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