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anti-ITGA4 immunotoxin 15A8 (IgG)-Gel (AGTO-L029G)

This immunotoxin was achieved by conjugating/fusing the Anti-ITGA4 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to breast cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of breast cancer.      
Datasheet
Specifications
Host
Mouse
Species Reactivity
Human
Clone
15A8
Molecule Class
IgG-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Breast cancer
Target
Alternative Names
269C wild type; Alpha 4 subunit of VLA 4 receptor; Antigen CD49D; Antigen CD49D, alpha 4 subunit of VLA 4 receptor; CD 49d; CD49 antigen like family member D; CD49 antigen-like family member D; CD49d
Entrez Gene ID
3676
UniProt ID
Q6PJE7

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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