anti-ITGA4 immunotoxin 15A8 (IgG)-Gel

CAT#: AGTO-L029G

This immunotoxin was achieved by conjugating/fusing the Anti-ITGA4 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to breast cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of breast cancer.

Gene Expression
Figure 1 IF staining of human cell line HaCaT Figure 2 RNA cell line category: Cell line enhanced (fHDF/TERT166, HEL, JURKAT, MOLT-4)

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • 15A8
  • Molecule Class
  • IgG-Gel
  • Toxin Description
  • Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Breast cancer

Target

  • Alternative Names
  • 269C wild type; Alpha 4 subunit of VLA 4 receptor; Antigen CD49D; Antigen CD49D, alpha 4 subunit of VLA 4 receptor; CD 49d; CD49 antigen like family member D; CD49 antigen-like family member D; CD49d; CD49d antigen; CDw49d; IA4; Integrin alpha 4; Integrin alpha 4 subunit; Integrin alpha IV; Integrin alpha-4; Integrin alpha-IV; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor); ITA4_HUMAN; ITGA 4; ITGA4; LPAM23; MGC90518; OTTHUMP00000205320; Very Late Activation Antigen 4; Very Late Activation Protein 4 Receptor Alpha 4 Subunit; Very late activation protein 4 receptor, alpha 4 subunit; VLA 4; VLA 4 subunit alpha; VLA-4 subunit alpha; VLA4; Breast cancer; Gelonin; Gel
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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