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ITGA4
Loading...Anti-ITGA4 Recombinant Antibody Products
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- Derivation: Humanized (from rat)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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- Anti-human ITGA4 scFv Fragment (IN 10) (TAB-717LC-S(P))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Anti-human ITGA4 Fab Fragment (IN 10) (TAB-717LC-F(E))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Recombinant Mouse Anti-ITGA4 Antibody (NEUT-1549CQ) (NEUT-1549CQ)
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- Species Reactivity: Human
- Type: IgG1
- Application: BL
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- Recombinant Rat Anti-Itga4 Antibody (9C10(MFR4.B)) (NEUT-1550CQ)
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- Species Reactivity: Mouse
- Type: IgG2a, κ
- Application: FC, BL, IHC
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- Recombinant Rat Anti-Itga4 Antibody (R1-2) (NEUT-1551CQ)
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- Species Reactivity: Mouse
- Type: IgG2b, κ
- Application: FC, IP, BL, IHC
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- Recombinant Mouse Anti-ITGA4 Antibody (9F10) (FN-177CQ)
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- Species Reactivity: Rhesus monkey, Human
- Type: Mouse IgG1, κ
- Application: FC, FuncS, ELISA, FC
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- Mouse Anti-ITGA4 Recombinant Antibody (clone HP2/1) (HPAB-0083-YJ)
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- Species Reactivity: Human, Rat, Rhesus Monkey, Bovine, Pig, Cynomolgus monkey, Goat, Rabbit, Llama, Horse, Mink, Mustelid, Cat
- Type: Mouse IgG1
- Application: FC, FuncS, IHC-Fr, IP
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- Human Anti-ITGA4 Recombinant Antibody (clone IN9A) (HPAB-0466-YJ)
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- Derivation: Fab Phage display library
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC, Block
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- Human Anti-ITGA4 Antibody (clone MAb 21.6), mRNA (PABL-249-mRNA)
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- Species Reactivity: Human
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- Recombinant Rat Anti-Itga4 Antibody (PS/2) (NEUT-1552CQ)
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- Species Reactivity: Mouse
- Type: IgG2b
- Application: FC, BL
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- Derivation: Humanized (from rat)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: IF, IP, Neut, FuncS, ELISA, FC
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- Recombinant Mouse Anti-ITGA4 Antibody (BU49) (FN-044CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, Block
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- Mouse Anti-ITGA4 Recombinant Antibody (clone K49) (VS3-WK1481)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, IF
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- Mouse Anti-ITGA4 Recombinant Antibody (clone TA2) (HPAB-1588WJ)
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- Derivation: Hybridoma
- Species Reactivity: Rat
- Type: Mouse IgG
- Application: ELISA, WB
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- Mouse Anti-ITGA4 Recombinant Antibody (clone HP1 / 2) (HPAB-1620WJ)
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- Derivation: Hybridoma
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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- Recombinant Rat Anti-Itga4 Antibody (CBL914) (NEUT-1553CQ)
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- Species Reactivity: Mouse
- Type: IgG2a, κ
- Application: FC, Neut
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- Human Anti-ITGA4 Recombinant Antibody (clone huHP1 / 2) (HPAB-1621WJ)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone TA2) (HPAB-1588WJ-F(E))
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- Derivation: Hybridoma
- Species Reactivity: Rat
- Type: Mouse Fab
- Application: ELISA, WB
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- Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone HP1 / 2) (HPAB-1620WJ-F(E))
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- Derivation: Hybridoma
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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- Human Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone huHP1 / 2) (HPAB-1621WJ-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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- Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone TA2) (HPAB-1588WJ-S(P))
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- Derivation: Hybridoma
- Species Reactivity: Rat
- Type: Mouse scFv
- Application: ELISA, WB
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- Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone HP1 / 2) (HPAB-1620WJ-S(P))
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- Derivation: Hybridoma
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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- Human Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone huHP1 / 2) (HPAB-1621WJ-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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- Human Anti-ITGA4 Recombinant Antibody (clone IN9A); scFv Fragment (HPAB-0466-YJ-S(P))
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- Derivation: Fab Phage display library
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, Block
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- Human Anti-ITGA4 Recombinant Antibody (clone IN9A); Fab Fragment (HPAB-0466-YJ-F(E))
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- Derivation: Fab Phage display library
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC, Block
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- anti-ITGA4 immunotoxin 15A8 (IgG)-Gel (AGTO-L029G)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Human Anti-ITGA4 scFv-Fc Chimera (VS-0425-FY55) (VS-0425-FY55)
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- Species Reactivity: Human
- Type: Human IgG4, scFv-Fc
- Application: ELISA
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For Research Use Only. Not For Clinical Use.
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein class
Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Erythroid cells, dendritic cells, Plasma cells, T-cells, NK-cells, B-cells, monocytes, Macrophages)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (fHDF/TERT166, HEL, JURKAT, MOLT-4)
Interaction
Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). Interacts with MDK (PubMed:15466886). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886).
Molecular function
Integrin, Receptor
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