Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins
Intracellular, Membrane (different isoforms)
Group enriched (Erythroid cells, dendritic cells, Plasma cells, T-cells, NK-cells, B-cells, monocytes, Macrophages)
Low immune cell specificity
Cell line enhanced (fHDF/TERT166, HEL, JURKAT, MOLT-4)
Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415). Interacts with MDK (PubMed:15466886). ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886).
Integrin, Receptor
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For Research Use Only. Not For Clinical Use.