Human Anti-ITGA4 scFv-Fc Chimera (VS-0425-FY55) (CAT#: VS-0425-FY55)
The anti-ITGA4 scFv-Fc fusion protein is designed to selectively target integrin alpha-4 (ITGA4), a key mediator of leukocyte adhesion and migration. This protein combines a single-chain variable fragment (scFv) for precise ITGA4 binding with an Fc domain, optimizing stability and extending its systemic half-life. By inhibiting ITGA4, it aims to disrupt the trafficking of inflammatory cells, thereby reducing inflammation in conditions such as inflammatory bowel disease and multiple sclerosis. The Fc portion of the protein enhances its persistence in the body. Research efforts are focused on evaluating its therapeutic potential for mitigating immune-mediated diseases. This targeted approach has the capacity to decrease harmful movement of inflamatory cells.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74961/1608_C10_1_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74961/1608_C10_1_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (fHDF/TERT166, HEL, JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115232-ITGA4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115232-ITGA4
Specifications
- Immunogen
- RAMOS cell line as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human ITGA4
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Multiple sclerosis, Crohn's disease and inflammatory bowel disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Integrin Subunit Alpha 4
- Gene ID
- 3676
- UniProt ID
- P13612
- Long Name
- Integrin Subunit Alpha 4
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Phosphorylation on Ser-1027 inhibits PXN binding.
Glycosylation at Asn79, Asn138, Asn229, Asn480, Asn518, Asn538, Asn626, Asn645, Asn660, Asn806, and Asn821
Ubiquitination at Lys95, Lys116, Lys149, Lys190, Lys241, Lys280, Lys289, Lys363, Lys590, Lys614, Lys760, Lys771, Lys867, Lys892, and Lys1028
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 12 sites, 24 N-linked glycans (9 sites)
- Protein Refseq
- NP_000876.3; NP_001303241.1
- Function
- Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin.
They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin.
They are also receptors for VCAM1.
Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1.
Integrin alpha-4/beta-7 is also a receptor for MADCAM1.
It recognizes the sequence L-D-T in MADCAM1.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| TAB-135 | Anti-Human Integrin alpha 4 beta 7 Recombinant Antibody (Etrolizumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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