Anti-Integrin alpha 4 antibody is a Mouse antibody of IgG class that binds to an Integrin alpha 4.
Figure 1 Binding of mAb ACT-1 to RMPI8866 cells.
RPMI8866 cells (0.5 x106) were incubated with 1 μg APC labeled ACT-1 (α4β7 specific antibody). Antibody binding was measured by flow cytometry and is presented as a histogram. Over 99% of the RPMI8866 cells expressed α4β7 integrin. Unstained cells (grey shading) and isotype control antibody (solid line) were used as controls.
Peachman, K. K., Karasavvas, N., Chenine, A. L., McLinden, R., Rerks-Ngarm, S., Jaranit, K., ... & Michael, N. L. (2015). Identification of new regions in HIV-1 gp120 variable 2 and 3 loops that bind to α4β7 integrin receptor. PLoS One, 10(12), e0143895.
Figure 2 Inhibition of binding of α4β7 integrin receptor to MAdCAM-1.
RMPI8866 cells were incubated with media only (solid circles) or with ACT-1 (0.5 μg/well; open circles, left panel) and then added to MAdCAM-1 (natural ligand of α4β7 integrin; 0.2 μg/well) coated plates. The plates were washed and 100 μl of media and 10 μl of AlamarBlue® dye were added to each well. Fluorescence was measured immediately after the addition of the dye (time 0) and then at 2 hours intervals for 8 hours. The percent inhibition at the 8 hour time point is shown.
Peachman, K. K., Karasavvas, N., Chenine, A. L., McLinden, R., Rerks-Ngarm, S., Jaranit, K., ... & Michael, N. L. (2015). Identification of new regions in HIV-1 gp120 variable 2 and 3 loops that bind to α4β7 integrin receptor. PLoS One, 10(12), e0143895.
Figure 3 Binding of α4β7 integrin receptor to cyclic and linear V2 peptides.
RMPI8866 cells were incubated with media (solid circles), ACT-1 (open circles) and then added to (B) linear (left panel), cyclic V2 peptides (TH023, MN, and acute C, second, third and right panels, respectively), or (C) cyclic V3 peptides (TH023, left panel, MN, middle panel, and acute C, right panel) coated plates respectively. The plates were washed and 100 μl of media and 10 μl of AlamarBlue® dye was added to each well. Fluorescence was measured immediately after the addition of the dye (time 0) and then at 2 hour intervals for 8 hours. The percent inhibition at the 8 hour time point is shown in each panel.
Peachman, K. K., Karasavvas, N., Chenine, A. L., McLinden, R., Rerks-Ngarm, S., Jaranit, K., ... & Michael, N. L. (2015). Identification of new regions in HIV-1 gp120 variable 2 and 3 loops that bind to α4β7 integrin receptor. PLoS One, 10(12), e0143895.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-135 | Anti-Human Integrin alpha 4 beta 7 Recombinant Antibody (Etrolizumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L029G | anti-ITGA4 immunotoxin 15A8 (IgG)-Gel | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-249 | Human Anti-ITGA4 Recombinant Antibody (clone MAb 21.6) | Neut, FuncS | Human IgG |
MRO-0848-CN | Recombinant Rabbit Anti-ITGA4 Monoclonal Antibody (JA09-36) | WB, IHC, FC | Rabbit IgG |
VS3-XY898 | Mouse Anti-ITGA4 Recombinant Antibody, FITC (clone 4ABU49) | FC, IF | Mouse IgG1 |
VS3-XY899 | Mouse Anti-ITGA4 Recombinant Antibody, PE (clone 4ABU49) | FC, IF | Mouse IgG1 |
VS3-XY900 | Mouse Anti-ITGA4 Recombinant Antibody (clone 4ABU49) | FC, IF | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-249 | Human Anti-ITGA4 Recombinant Antibody (clone MAb 21.6); scFv Fragment | Neut, FuncS | Human scFv |
HPAB-0466-YJ-S(P) | Human Anti-ITGA4 Recombinant Antibody (clone IN9A); scFv Fragment | ELISA, FC, Block | Human scFv |
HPAB-1588WJ-S(P) | Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone TA2) | ELISA, WB | Mouse scFv |
HPAB-1620WJ-S(P) | Mouse Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone HP1 / 2) | ELISA, WB | Mouse scFv |
HPAB-1621WJ-S(P) | Human Anti-ITGA4 Recombinant Antibody; scFv Fragment (clone huHP1 / 2) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-249 | Human Anti-ITGA4 Recombinant Antibody (clone MAb 21.6); Fab Fragment | Neut, FuncS | Human Fab |
HPAB-0466-YJ-F(E) | Human Anti-ITGA4 Recombinant Antibody (clone IN9A); Fab Fragment | ELISA, FC, Block | Human Fab |
HPAB-1588WJ-F(E) | Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone TA2) | ELISA, WB | Mouse Fab |
HPAB-1620WJ-F(E) | Mouse Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone HP1 / 2) | ELISA, WB | Mouse Fab |
HPAB-1621WJ-F(E) | Human Anti-ITGA4 Recombinant Antibody; Fab Fragment (clone huHP1 / 2) | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-717LC | Anti-human ITGA4 Recombinant Antibody (IN 10) (TAB-717LC) | ELISA | Human antibody |
TAB-717LC-S(P) | Anti-human ITGA4 scFv Fragment (IN 10) | ELISA | Human antibody |
TAB-717LC-F(E) | Anti-human ITGA4 Fab Fragment (IN 10) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-122-S (P) | Recombinant Mouse Anti-Integrin alpha 4 Antibody scFv Fragment (ACT-1) | Neut, FuncS | scFv |
PABX-122-F (E) | Recombinant Mouse Anti-Integrin alpha 4 Antibody Fab Fragment (ACT-1) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1549CQ | Recombinant Mouse Anti-ITGA4 Antibody (2B4) | BL | IgG1 |
NEUT-1550CQ | Recombinant Rat Anti-Itga4 Antibody (9C10(MFR4.B)) | FC, BL, IHC | IgG2a, κ |
NEUT-1551CQ | Recombinant Rat Anti-Itga4 Antibody (R1-2) | FC, IP, BL, IHC | IgG2b, κ |
NEUT-1552CQ | Recombinant Rat Anti-Itga4 Antibody (PS/2) | FC, BL | IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1553CQ | Recombinant Rat Anti-Itga4 Antibody (CBL914) | FC, Neut | IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1873 | Hi-Affi™ Recombinant Rabbit Anti-ITGA4 Monoclonal Antibody (DS1873AB) | ICC/IF, IHC-P, IP, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-135 | Afuco™ Anti-ITGA4 ADCC Recombinant Antibody (Etrolizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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