The anti-osteopontin antibodies target differen forms of Opn (full length, ThrOpn and MmpOpn), which has different functions in biomineralization, bone remodeling, immune function and heart. The anti-Opn antibody can be used in treatment and/or prevention of chronic inflammatory disease such as type-2 diabetes (T2D) and cardiovascular disease.
Figure 1 ELISA of mAbs against either full length Opn (flOpn), thrombin cleaved Opn (ThrOpn), or metalloproteinase cleaved Opn (MmpOpn).
mAbs 7-5-4 shows a minor cross-reactivity towards ThrOpn but are highly reactive towards MmpOpn.
Figure 2 Immunoreactivity of mAbs in Western Blot analysis against either flOpn (lane 1-4), ThrOpn (lane 5-6), or MmpOpn (lane 7-8).
mAbs 7-5-4 shows binding to both cleaved Opn forms but are clearly more reactive towards MmpOpn.
Figure 3 Assessment of functional activity of mAbs.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1403z | Mouse Anti-SPP1 Recombinant Antibody (clone 23F4) | ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
MOB-1506CT | Recombinant Mouse anti-Human SPP1 Monoclonal antibody (EML2283) | WB | |
HPAB-0569-YJ | Human Anti-SPP1 Recombinant Antibody (clone OPN-3) | ELISA | Human IgG |
FAMAB-1252CQ | Human Anti-SPP1 Recombinant Antibody (clone hu1A12) | WB, IF, ELISA, Inhib, Cyt | Human IgG1 |
ZG-0075U | Rabbit Anti-SPP1 Recombinant Antibody (clone 10A1) | ELISA, WB, IHC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0258CL | Anti-Human SPP1 Recombinant Antibody (mAb 4-4-2) | ELISA, WB | |
TAB-0259CL | Anti-Human SPP1 Recombinant Antibody (mAb 7-5-4) | ELISA, WB | |
TAB-0260CL | Anti-Human SPP1 Recombinant Antibody (mAb 9-3-1) | ELISA, WB | |
TAB-0261CL | Anti-Human SPP1 Recombinant Antibody (mAb 21-5-4) | ELISA, WB | |
TAB-0843CL | Anti-Human SPP1 Recombinant Antibody (2K1) | sELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0846CL | Anti-Human SPP1 Recombinant Antibody (MOR-6990) | ELISA, Neut | Human antibody |
TAB-0847CL | Anti-Human SPP1 Recombinant Antibody (MOR-6991) | ELISA | Human antibody |
TAB-0848CL | Anti-Human SPP1 Recombinant Antibody (MOR-6993) | ELISA, FuncS, Neut | Human antibody |
TAB-0846CL-S(P) | Anti-Human SPP1 Recombinant Antibody scFv Fragment (MOR-6990) | ELISA | Human antibody |
TAB-0847CL-S(P) | Anti-Human SPP1 Recombinant Antibody scFv Fragment (MOR-6991) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0814MZ | Chicken Anti-Osteopontin Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3394 | Hi-Affi™ Recombinant Rabbit Anti-SPP1 Monoclonal Antibody (DS3394AB) | FC, ICC/IF, IHC-P, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0068-YC-S(P) | Human Anti-SPP1 Recombinant Antibody (clone h2K1); scFv Fragment | FuncS | Humanized scFv |
HPAB-1079WJ-S(P) | Human Anti-SPP1 Recombinant Antibody (clone MOR-6990); scFv Fragment | ELISA | Human scFv |
HPAB-1080WJ-S(P) | Human Anti-SPP1 Recombinant Antibody (clone MOR-6991); scFv Fragment | ELISA | Human scFv |
HPAB-1081WJ-S(P) | Human Anti-SPP1 Recombinant Antibody (clone MOR-6993); scFv Fragment | ELISA | Human scFv |
HPAB-0569-YJ-S(P) | Human Anti-SPP1 Recombinant Antibody (clone OPN-3); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0068-YC-F(E) | Human Anti-SPP1 Recombinant Antibody (clone h2K1); Fab Fragment | FuncS | Humanized Fab |
HPAB-0069-YC-F(E) | Human Anti-SPP1 Recombinant Antibody (clone c2K1); Fab Fragment | FuncS | Human Fab |
HPAB-0070-YC-F(E) | Human Anti-SPP1 Recombinant Antibody (clone R2K1v1.7); Fab Fragment | ELISA | Humanized Fab |
HPAB-1079WJ-F(E) | Human Anti-SPP1 Recombinant Antibody (clone MOR-6990); Fab Fragment | ELISA | Human Fab |
HPAB-0569-YJ-F(E) | Human Anti-SPP1 Recombinant Antibody (clone OPN-3); Fab Fragment | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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