Anti-Human SPP1 Recombinant Antibody scFv Fragment (mAb 7-5-4) (CAT#: TAB-0259CL-S(P))
The anti-osteopontin antibodies target differen forms of Opn (full length, ThrOpn and MmpOpn), which has different functions in biomineralization, bone remodeling, immune function and heart. The anti-Opn antibody can be used in treatment and/or prevention of chronic inflammatory disease such as type-2 diabetes (T2D) and cardiovascular disease.
Specific Inquiry
-1.png)
Figure 1 ELISA of mAbs against either full length Opn (flOpn), thrombin cleaved Opn (ThrOpn), or metalloproteinase cleaved Opn (MmpOpn).
mAbs 7-5-4 shows a minor cross-reactivity towards ThrOpn but are highly reactive towards MmpOpn.
-2.png)
Figure 2 Immunoreactivity of mAbs in Western Blot analysis against either flOpn (lane 1-4), ThrOpn (lane 5-6), or MmpOpn (lane 7-8).
mAbs 7-5-4 shows binding to both cleaved Opn forms but are clearly more reactive towards MmpOpn.
-3.png)
Figure 3 Assessment of functional activity of mAbs.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- mAb 7-5-4
- Applications
- ELISA, WB, FuncS
- Related Disease
- Type-2 diabetes (T2D), cardiovascular disease
Applications
- Application Notes
- The antibody was validated for ELISA, Western blot and Function assay. For details, refer to Published Data.
Target
- Alternative Names
- SPP1; secreted phosphoprotein 1; OPN; BNSP; BSPI; ETA-1; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
- Gene ID
- 6696
- UniProt ID
- A0A024RDE6
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody
Mouse Antibody
Recombinant Antibody
Chicken IgY Antibody
Rabbit Monoclonal Antibody
Fab Fragment Antibody
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0846CL | Anti-Human SPP1 Recombinant Antibody (MOR-6990) | ELISA, Neut | Human antibody |
| TAB-0847CL | Anti-Human SPP1 Recombinant Antibody (MOR-6991) | ELISA | Human antibody |
| TAB-0846CL-F(E) | Anti-Human SPP1 Recombinant Antibody Fab Fragment (MOR-6990) | ELISA | Human antibody |
| TAB-0847CL-F(E) | Anti-Human SPP1 Recombinant Antibody Fab Fragment (MOR-6991) | ELISA | Human antibody |
| TAB-0848CL-F(E) | Anti-Human SPP1 Recombinant Antibody Fab Fragment (MOR-6993) | ELISA | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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