Llama Anti-STAT3 VHH Single Domain Antibody

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Citations

1. Singh, Sunanda, et al. "Suppression of breast cancer cell proliferation by selective single-domain antibody for intracellular STAT3." Breast cancer: basic and clinical research 12 (2018): 1178223417750858. https://doi.org/10.1177/1178223417750858
   This study investigated the suppression of breast cancer cell proliferation through the use of a selective single-domain antibody targeting intracellular STAT3, a transcription factor known to be constitutively activated in many human malignancies. The researchers generated a variable region of camelid heavy chain (VHH) antibody named SBT-100 (anti-STAT3 B VHH13) by immunizing camelids with human STAT3. The antibody specifically binds to STAT3 and its phosphorylated form (p-STAT3), thereby inhibiting their function. The efficacy of SBT-100 was tested in various breast cancer cell lines and a xenograft model using athymic mice, demonstrating significant inhibition of tumor growth and cell proliferation without any observable toxicity.
   Creative Biolabs provided the phagemid pCDisplay-3M used in the construction of the VHH library and the VHHs against STAT3 (Cat#: MOB-113CQ) for immunoprecipitation assays. These VHHs were crucial for isolating STAT3-specific antibodies. The tools supplied by Creative Biolabs were essential in generating and characterizing the VHH antibodies that specifically target STAT3. This enabled the researchers to demonstrate the potential therapeutic effects of SBT-100 in suppressing breast cancer cell proliferation and tumor growth.

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(Creative Biolabs Cat# MOB-113CQ, RRID: AB_3111486)

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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