Human Anti-STAT3 scFv-Fc Chimera (VS-0425-FY28) (CAT#: VS-0425-FY28)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human STAT3

• Species Reactivity
• Human

• Applications
• ELISA, Immunofluorescence

• Related Disease
• Hyper-Ige Syndrome 1, Autosomal Dominant, With Recurrent Infections and Autoimmune Disease, Multisystem, Infantile-Onset, 1

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 20 ug/mL
  Immunofluorescence: 10 ug/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Signal transducer and activator of transcription 3; Stat3

• Long Name
• Signal transducer and activator of transcription 3

• Sequence Similarities
• Belongs to the transcription factor STAT family.

• Cellular Localization
• Cytoplasm; Nucleus

• Post Translation Modifications
• Tyrosine phosphorylated upon stimulation with EGF.
  Acetylated on lysine residues by EP300/p300, promoting its activation.
  Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity.
  Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.
  (Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA.
  Ubiquitination at Lys87, Lys97, Lys177, Lys180, Lys244, Lys294, and Lys709
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 6 sites, 2 O-linked glycans (6 sites)

• Protein Refseq
• XP_016880462.1; XP_047292541.1; XP_047292542.1; XP_054172966.1; XP_054172967.1

• Function
• Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors.
  Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene.
  May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
  Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes.
  Activated by IL31 through IL31RA

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