Anti-Human TNFRSF10B Recombinant Antibody (AU12)
CAT#: TAB-254MZ
This product is an anti-DR5 antibody with improved affinity and stability that specifically binds to the death receptor 5 to destroy cancer cells effectively.
Published Data
Gene Expression
FuncS
Figure 1 shows the results of measuring the stability of AU11 and AU12.
ELISA
Figure 2 is a diagram shows the result of measuring the same antigen binding site between HW1 and AU11 or AU12 using a competitive ELISA.
FuncS
Figure 3 is a diagram shows the results of comparing and evaluating the degree of apoptosis of HW1, AU11, and AU12 in HCT116, a human colorectal cancer cell line by MTT-assay.
FuncS
Figure 4 shows MTT-assay of apoptosis ability of HW1, AU11 and AU12 in the presence of various inhibitors (Z-VAD, SP600125, SB203580, 3-MA, Chloroguine) in human colon cancer cell line HCT116. It is a figure which shows the result of analysis.
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Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
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Specifications
- Host Species
- Human
- Derivation
- Antibody library
- Type
- Human antibody
- Specificity
- Human
- Clone
- AU12
- Applications
- ELISA, FuncS
- Related Disease
- Cancers caused by DR5 expression
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay.
Target
- Alternative Names
- TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer)
- Gene ID
- 8795
- UniProt ID
- O14763
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
See other products for "TNFRSF10B"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-052 | Recombinant Anti-human TNFRSF10B VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| HPAB-0703-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0703-YJ-VHH) | ELISA, Apop | Camelid VHH |
| HPAB-0704-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0704-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-203 | Human Anti-TNFRSF10B Recombinant Antibody (TAB-203) | ELISA, IP, FC, FuncS, Neut, IF, ICC | Human IgG1, κ |
| TAB-195 | Anti-Human TRAIL-R2 Recombinant Antibody (TAB-195) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - lambda |
| TAB-180 | Anti-Human DR5 Recombinant Antibody (TAB-180) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - lambda |
| TAB-253MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU11) | FC, ELISA | Human antibody |
| TAB-254MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU12) | FC, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-196 | Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 |
| TAB-250MZ | Human Anti-TNFRSF10B Recombinant Antibody (TAB-250MZ) | FuncS | Humanized IgG |
| TAB-251MZ | Human Anti-TNFRSF10B Recombinant Antibody (TAB-251MZ) | FuncS | Humanized IgG |
| TAB-250MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-250MZ-F(E)) | FC, ELISA | Humanized Fab |
| TAB-251MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-251MZ-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-625CL | Human Anti-TNFRSF10B Recombinant Antibody (TAB-625CL) | ELISA | Single Domain Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-029 | Human Anti-TNFRSF10B Recombinant Antibody (PABL-029) | WB, ELISA, FuncS | Human IgG |
| PABL-030 | Human Anti-TNFRSF10B Recombinant Antibody (PABL-030) | WB, ELISA, FuncS | Human IgG |
| HPAB-0412-CN | Human Anti-TNFRSF10B Recombinant Antibody (HPAB-0412-CN) | WB, ELISA | Human IgG1, λ |
| FN-235CQ | Hamster Anti-Tnfrsf10b Recombinant Antibody (clone MD5-1) | FC, FuncS | Hamster IgG |
| HPAB-1180WJ | Human Anti-TNFRSF10B Recombinant Antibody (clone TRA-8) | Cyt, IF, Inhib, WB, ELISA, FC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-029 | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBL-030 | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (PSBL-030) | WB, ELISA, FuncS | Human scFv |
| HPAB-M0231-YC-S(P) | Human Anti-TNFRSF10B Recombinant Antibody (clone TR2-3); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-N0268-YC-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-N0268-YC-S(P)) | FC, Inhib | Human scFv |
| HPAB-0416-YJ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0416-YJ-S(P)) | ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-123 | Human Anti-TNFRSF10B Recombinant Antibody (clone BDF1); Fab Fragment | ELISA | Human Fab |
| HPAB-0672YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0672YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0673YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0673YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0674YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0674YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0675YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0675YY-F(E)) | ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-247MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-247MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-248MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-248MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-249MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-249MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-252MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment | ELISA | |
| TAB-247MZ-F(E) | Mouse Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-247MZ-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3604 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone DS3604AB), PE | FC, WB | Rabbit IgG |
| MOR-3605 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone DS3605AB) | ELISA | Rabbit IgG |
| MOR-4468 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone SI562DS) | ELISA | Rabbit IgG |
| MOR-4469 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI563DS) | ELISA, FC | Rabbit IgG |
| MOR-4473 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI567DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104LC | Human Anti-TNFRSF10B Recombinant Antibody (MOB-104LC) | FuncS | Chimeric (mouse/human) IgG1, κ |
| VS-0724-XY43 | Mouse Anti-TNFRSF10B Agonistic Antibody (VS-0724-XY43) | Agonistic assays | Mouse IgG1 |
| VS-0724-XY44 | Mouse Anti-TNFRSF10B Agonistic Antibody (clone B-D37) | ELISA, FC, FuncS, IP | Mouse IgG2b, kappa |
| VS-0724-XY60 | Human Anti-TNFRSF10B Agonistic Antibody (clone AMG 655) | ELISA, Agonistic assays | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-196 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-196) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-203 | Afuco™ Anti-TNFRSF10B Recombinant Antibody (AFC-TAB-203), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | Human IgG1, κ |
| AFC-TAB-180 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-180) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-195 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-195) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY72 | Human Anti-TNFRSF10B (clone Lexatumumab) scFv-Fc Chimera | ELISA, IP, FC, FuncS, Neut, IF, ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC222 | Recombinant Anti-TNFRSF10B Vesicular Antibody, EV Displayed (VS-0425-YC222) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7361 | Anti-Mouse TNFRSF10B Immunohistochemistry Kit | IHC | |
| VS-0525-XY7362 | Anti-Monkey TNFRSF10B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC232 | Recombinant Anti-TNFRSF10B (ECD x DD) Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
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