Anti-Human DR5 Recombinant Antibody (TAB-180) (CAT#: TAB-180)
Recombinant monoclonal antibody to DR5. It is a human monoclonal antibody designed for the treatment of cancers.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
(Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
Figure 2 Colon
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
Figure 3 Liver
(Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
(Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
Figure 4 Kidney
(Cells in glomeruli
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
(Cells in glomeruli
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
(Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
Figure 6 Lymph node
(Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
(Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - lambda
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- FuncS, IF, Neut, ELISA, FC, IP, ICC, WB, Activ, SPR
- MW
- 143.1 kDa
- Related Disease
- Colorectal cancers
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The TNFRSF10B antibody has been reported in applications of FuncS, IF, Neut, ELISA, FC, IP, ICC, WB, Activ, SPR.
Target
- Alternative Names
- Drozitumab;912628-39-8;PRO95780;anti-DR5;rhuMAb DR5;TNFRSF10B;tumor necrosis factor receptor superfamily, member 10b;tumor necrosis factor receptor superfamily member 10B;CD262;DR5;KILLER;TRAIL R2;TRICK2A;TRICKB;Fas-like protein;death receptor 5;cytotoxic
- Gene ID
- 8795
- UniProt ID
- O14763
Related Resources
Please refer to Drozitumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Drozitumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1172z | Mouse Anti-TNFRSF10B Recombinant Antibody (clone 40C9) | FC, ICC, IHC, IP, FuncS | Mouse IgG1 |
| FAMAB-0324-CN-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (clone 4E6) | WB, ELISA, FC, IHC, IP | Camelid VHH |
| HPAB-M0231-YC | Human Anti-TNFRSF10B Recombinant Antibody (clone TR2-3) | ELISA, WB | Human IgG |
| HPAB-0416-YJ | Mouse Anti-TNFRSF10B Recombinant Antibody (HPAB-0416-YJ) | ELISA, FuncS, FC | Mouse IgG |
| HPAB-0417-YJ | Human Anti-TNFRSF10B Recombinant Antibody (HPAB-0417-YJ) | ELISA, FuncS, FC | Chimeric (Mouse/Human) IgG1 |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-180, RRID: AB_3111853)
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Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: Neut, ELISA, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: ELISA, FC
Application: ELISA, FC, Inhib
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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