Anti-Human DR5 Recombinant Antibody (TAB-180)

Name: Anti-Human DR5 Recombinant Antibody (TAB-180)
SKU: TAB-180
Rating: 5 (1 reviews)

CAT#: TAB-180

Recombinant monoclonal antibody to DR5. It is a human monoclonal antibody designed for the treatment of cancers.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

Neuropil
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg

Normal Tissue Figure 6 Lymph node

Non-germinal center cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B

❮

❯

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
IgG1 - lambda

Specificity
Tested positive against native human antigen.

Species Reactivity
Human

Applications
FuncS, IF, Neut, ELISA, FC, IP, ICC, WB, Activ, SPR

MW
143.1 kDa

Related Disease
Colorectal cancers

Product Property

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Applications

Application Notes
The TNFRSF10B antibody has been reported in applications of FuncS, IF, Neut, ELISA, FC, IP, ICC, WB, Activ, SPR.

Target

Alternative Names
Drozitumab;912628-39-8;PRO95780;anti-DR5;rhuMAb DR5;TNFRSF10B;tumor necrosis factor receptor superfamily, member 10b;tumor necrosis factor receptor superfamily member 10B;CD262;DR5;KILLER;TRAIL R2;TRICK2A;TRICKB;Fas-like protein;death receptor 5;cytotoxic

Gene ID
8795

UniProt ID
O14763

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(Creative Biolabs Cat# TAB-180, RRID: AB_3111853)

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Biosimilar Overview

Please refer to Drozitumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Drozitumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-180.pdf

MSDS

MSDS - TAB-180.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
PFBC-123	Human Anti-TNFRSF10B Recombinant Antibody (clone BDF1); Fab Fragment	ELISA	Human Fab
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HPAB-0672YY-F(E)	Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0672YY-F(E))	ELISA, FuncS	Humanized Fab
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CAT	Product Name	Application	Type
TAB-247MZ	Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-247MZ)	ELISA, FC, FuncS, Inhib	Mouse IgG3, κ
TAB-247MZ-F(E)	Mouse Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-247MZ-F(E))	ELISA, WB	Mouse Fab
TAB-248MZ-F(E)	Mouse Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-248MZ-F(E))	FC, ELISA	Mouse Fab
TAB-249MZ-F(E)	Mouse Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-249MZ-F(E))	FC, ELISA	Mouse Fab
TAB-252MZ-F(E)	Anti-Human TNFRSF10B Recombinant Antibody Fab Fragment	ELISA

CAT	Product Name	Application	Type
TAB-250MZ	Human Anti-TNFRSF10B Recombinant Antibody (TAB-250MZ)	FuncS	Humanized IgG
TAB-251MZ	Human Anti-TNFRSF10B Recombinant Antibody (TAB-251MZ)	FuncS	Humanized IgG
TAB-250MZ-S(P)	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-250MZ-S(P))	FC, ELISA	Humanized scFv
TAB-250MZ-F(E)	Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-250MZ-F(E))	FC, ELISA	Humanized Fab
TAB-251MZ-F(E)	Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-251MZ-F(E))	FC, ELISA	Humanized Fab

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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VS-0724-XY44	Mouse Anti-TNFRSF10B Agonistic Antibody (clone B-D37)	ELISA, FC, FuncS, IP	Mouse IgG2b, kappa
VS-0724-XY60	Human Anti-TNFRSF10B Agonistic Antibody (clone AMG 655)	ELISA, Agonistic assays	Human IgG

CAT	Product Name	Application	Type
HPAB-0303-YC	Human Anti-TNFRSF10B Recombinant Antibody (HPAB-0303-YC)	ELISA, FuncS, Inhib	Humanized IgG1
HPAB-0304-YC	Human Anti-TNFRSF10B Recombinant Antibody (HPAB-0304-YC)	FuncS	Human IgG
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CAT	Product Name	Application	Type
HPAB-0303-YC-S(P)	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0303-YC-S(P))	ELISA, FuncS	Human scFv
HPAB-0304-YC-S(P)	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0304-YC-S(P))	FuncS	Human scFv
HPAB-1145WJ-S(P)	Mouse Anti-TNFRSF10B Recombinant Antibody (clone E-11-13); scFv Fragment	ELISA, FC	Mouse scFv
HPAB-1146WJ-S(P)	Mouse Anti-TNFRSF10B Recombinant Antibody (clone L-30-10); scFv Fragment	ELISA, FC	Mouse scFv
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CAT	Product Name	Application	Type
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AFC-TAB-203	Afuco™ Anti-TNFRSF10B Recombinant Antibody (AFC-TAB-203), ADCC Enhanced	ELISA, IP, FC, FuncS, Neut, IF	Human IgG1, κ
AFC-TAB-180	Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-180)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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