Recombinant Anti-TNFRSF10B (ECD x DD) Biparatopic Antibody, Tandem scFv (CAT#: VS-0525-YC232)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human TNFRSF10B

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Epitope 1
• The DR5 extracellular domain (ECD)

• Epitope 2
• The DR5 cytoplasmic death domain (DD)

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, FC, ICC, IF, IP, Neut

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• TNF Receptor Superfamily Member 10b

• Introduction
• The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

• Alternative Names
• TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5

• Gene ID
• 8795

• UniProt ID
• O14763

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