Human Anti-TNFRSF10B (clone Lexatumumab) scFv-Fc Chimera
CAT#: VS-0125-FY72
The anti-TNFRSF10B scFv-Fc antibody is a recombinant antibody that specifically targets the TNF receptor superfamily member 10B (TNFRSF10B), also known as TRAIL receptor 2 (TRAIL-R2). This antibody is engineered with a single-chain variable fragment (scFv) linked to an Fc region. The scFv domain provides high specificity and affinity for the target, while the Fc portion enhances the antibody's stability, solubility, and functionality, including effector functions like antibody-dependent cellular cytotoxicity (ADCC).
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- Lexatumumab
- Applications
- ELISA, Immunoprecipitation, Flow Cytometry, Functional Assay, Neutralization, Immunofluorescence, Antibody-dependent cellular cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The Anti-TNFRSF10B scFv-Fc antibody serves important functions in inducing apoptosis in cancer cells, potentially modulating immune responses, and serving as a valuable research tool. Its development could lead to novel strategies for cancer therapy.
Target
- Alternative Names
- TNF Receptor Superfamily Member 10b; Tumor Necrosis Factor Receptor Superfamily, Member 10b; TNF-Related Apoptosis-Inducing Ligand Receptor 2; Death Receptor 5; TRAIL-R2; TRAILR2; KILLER; TRICK2; ZTNFR9; DR5; P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer); Tumor Necrosis Factor Receptor Superfamily Member 10B; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9
- Gene ID
- 8795
- UniProt ID
- O14763
- Cellular Localization
- Membrane
- Post Translation Modifications
- (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
Ubiquitination at Lys245
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen (O14763) 2 sites, 2 O-linked glycans (2 sites)
- Protein Refseq
- NP_003833.4; NP_671716.2
- Function
- Receptor for the cytotoxic ligand TNFSF10/TRAIL.
The adapter molecule FADD recruits caspase-8 to the activated receptor.
The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Promotes the activation of NF-kappa-B.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "TNFRSF10B"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-052 | Recombinant Anti-human TNFRSF10B VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| HPAB-0703-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0703-YJ-VHH) | ELISA, Apop | Camelid VHH |
| HPAB-0704-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0704-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-196 | Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 |
| TAB-250MZ-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-250MZ-S(P)) | FC, ELISA | Humanized scFv |
| TAB-251MZ-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-251MZ-S(P)) | FC, ELISA | Humanized scFv |
| TAB-250MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-250MZ-F(E)) | FC, ELISA | Humanized Fab |
| TAB-251MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-251MZ-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195 | Anti-Human TRAIL-R2 Recombinant Antibody (TAB-195) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - lambda |
| TAB-180 | Anti-Human DR5 Recombinant Antibody (TAB-180) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - lambda |
| TAB-253MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU11) | FC, ELISA | Human antibody |
| TAB-254MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU12) | FC, ELISA | Human antibody |
| TAB-253MZ-F(E) | Anti-Human TNFRSF10B Recombinant Antibody Fab Fragment (AU11) | FC, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-625CL | Human Anti-TNFRSF10B Recombinant Antibody (TAB-625CL) | ELISA | Single Domain Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-029 | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBL-030 | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (PSBL-030) | WB, ELISA, FuncS | Human scFv |
| HPAB-0416-YJ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0416-YJ-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-0417-YJ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0417-YJ-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-0672YY-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0672YY-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-247MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-247MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-248MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-248MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-249MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-249MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-252MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment | ELISA | |
| TAB-247MZ-F(E) | Mouse Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-247MZ-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3604 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone DS3604AB), PE | FC, WB | Rabbit IgG |
| MOR-3605 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone DS3605AB) | ELISA | Rabbit IgG |
| MOR-4468 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone SI562DS) | ELISA | Rabbit IgG |
| MOR-4469 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI563DS) | ELISA, FC | Rabbit IgG |
| MOR-4473 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI567DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104LC | Human Anti-TNFRSF10B Recombinant Antibody (MOB-104LC) | FuncS | Chimeric (mouse/human) IgG1, κ |
| VS-0724-XY43 | Mouse Anti-TNFRSF10B Agonistic Antibody (VS-0724-XY43) | Agonistic assays | Mouse IgG1 |
| VS-0724-XY44 | Mouse Anti-TNFRSF10B Agonistic Antibody (clone B-D37) | ELISA, FC, FuncS, IP | Mouse IgG2b, kappa |
| VS-0724-XY60 | Human Anti-TNFRSF10B Agonistic Antibody (clone AMG 655) | ELISA, Agonistic assays | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0324-CN-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (clone 4E6) | WB, ELISA, FC, IHC, IP | Camelid VHH |
| FN-235CQ | Hamster Anti-Tnfrsf10b Recombinant Antibody (clone MD5-1) | FC, FuncS | Hamster IgG |
| VS3-QX1132 | Mouse Anti-TNFRSF10B Recombinant Antibody (clone 7F4-F8-G11) | WB, ICC | Mouse IgG1 |
| VS3-QX1133 | Mouse Anti-TNFRSF10B Recombinant Antibody (clone 4G12-F5-E9) | WB | Mouse IgG2b |
| VS3-QX1134 | Mouse Anti-TNFRSF10B Recombinant Antibody (clone 6F6-F5-D11) | WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-196 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-196) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-203 | Afuco™ Anti-TNFRSF10B Recombinant Antibody (AFC-TAB-203), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | Human IgG1, κ |
| AFC-TAB-180 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-180) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-195 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-195) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0231-YC-F(E) | Human Anti-TNFRSF10B Recombinant Antibody (clone TR2-3); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0672YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0672YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0673YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0673YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0674YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0674YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0675YY-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0675YY-F(E)) | ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC222 | Recombinant Anti-TNFRSF10B Vesicular Antibody, EV Displayed (VS-0425-YC222) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7361 | Anti-Mouse TNFRSF10B Immunohistochemistry Kit | IHC | |
| VS-0525-XY7362 | Anti-Monkey TNFRSF10B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC232 | Recombinant Anti-TNFRSF10B (ECD x DD) Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
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