Human Anti-TNFRSF10B (clone Lexatumumab) scFv-Fc Chimera (CAT#: VS-0125-FY72)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• Lexatumumab

• Applications
• ELISA, Immunoprecipitation, Flow Cytometry, Functional Assay, Neutralization, Immunofluorescence, Antibody-dependent cellular cytotoxicity

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The Anti-TNFRSF10B scFv-Fc antibody serves important functions in inducing apoptosis in cancer cells, potentially modulating immune responses, and serving as a valuable research tool. Its development could lead to novel strategies for cancer therapy.

• Alternative Names
• TNF Receptor Superfamily Member 10b; Tumor Necrosis Factor Receptor Superfamily, Member 10b; TNF-Related Apoptosis-Inducing Ligand Receptor 2; Death Receptor 5; TRAIL-R2; TRAILR2; KILLER; TRICK2; ZTNFR9; DR5; P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer); Tumor Necrosis Factor Receptor Superfamily Member 10B; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9

• Gene ID
• 8795

• UniProt ID
• O14763

• Cellular Localization
• Membrane

• Post Translation Modifications
• (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
  Ubiquitination at Lys245
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen (O14763) 2 sites, 2 O-linked glycans (2 sites)

• Protein Refseq
• NP_003833.4; NP_671716.2

• Function
• Receptor for the cytotoxic ligand TNFSF10/TRAIL.
  The adapter molecule FADD recruits caspase-8 to the activated receptor.
  The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
  Promotes the activation of NF-kappa-B.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

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