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    Anti-Human TRAIL-R2 Recombinant Antibody (TAB-195) (CAT#: TAB-195)

    Recombinant monoclonal antibody to TRAIL-R2. It is an experimental agonistic human monoclonal antibody against TRAIL-R2 (DR5, APO-2) undergoing clinical trials for the treatment of cancer.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Cerebral cortex
    Figure 1 Cerebral cortex
    (Endothelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous

    Neuropil
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Endothelial cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Glandular cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
    Figure 3 Liver
    Figure 3 Liver
    (Cholangiocytes
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Hepatocytes
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in glomeruli
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Cells in tubules
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Cells in seminiferous ducts
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Leydig cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
    Figure 6 Lymph node
    Figure 6 Lymph node
    (Non-germinal center cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
    RNA Expression
    Figure 7 RNA cell line category: Low cell line specificity
    Figure 7 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
    Figure 7 RNA cell line category: Low cell line specificity
    Figure 7 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B

    Specifications

    • Immunogen
    • The details of the immunogen for this antibody are not available.
    • Host Species
    • Human
    • Derivation
    • Human
    • Type
    • IgG1 - lambda
    • Specificity
    • Tested positive against native human antigen.
    • Species Reactivity
    • Human
    • Applications
    • ELISA, IP, FC, FuncS, Neut, IF, ICC
    • MW
    • 143.6 kDa
    • Related Disease
    • Cancers

    Product Property

    • Purity
    • >95.0% as determined by analysis by SDS-PAGE.
    • Storage
    • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • The TNFRSF10B antibody has been reported in applications of IP, WB.

    Target

    • Alternative Names
    • Lexatumumab;845816-02-6;ETR2-ST01;HGS-ETR2;HGS1018;ETR2-ST01;TNFRSF10B;tumor necrosis factor receptor superfamily, member 10b;tumor necrosis factor receptor superfamily member 10B;CD262;DR5;KILLER;TRAIL R2;TRICK2A;TRICKB;Fas-like protein;death receptor 5;

    Related Resources

    • Biosimilar Overview
    Please refer to Lexatumumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lexatumumab.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "TNFRSF10B"

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    Please select product type
    Single Domain Antibodies Humanized Antibodies Human Antibodies Rat Antibodies ScFv Antibodies Mouse Antibodies Rabbit Monoclonal Antibodies Agonistic Antibodies ADCC Enhanced Antibodies Fab Antibodies IgG Antibodies ScFv-Fc Chimeras Extracellular Vesicle Antibodies IHC Kits & Antibodies Biparatopic Antibodies
    CAT Product Name Application Type
    NABL-052 Recombinant Anti-human TNFRSF10B VHH Single Domain Antibody WB, ELISA, IHC, FC, FuncS Llama VHH
    HPAB-0703-YJ-VHH Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0703-YJ-VHH) ELISA, Apop Camelid VHH
    HPAB-0704-YJ-VHH Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0704-YJ-VHH) ELISA Camelid VHH

    Customer Reviews and Q&As

    Customer Review Q&As

    Submit a review or a question

    Michael White
    Excellent for TRAIL-R2 Research
    The Anti-Human TRAIL-R2 Therapeutic Antibody (Lexatumumab) has been excellent for our TRAIL-R2 studies. Its specificity and sensitivity are outstanding, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
    20.Aug,23
    Laura Scott
    Effective and Dependable
    We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for TRAIL-R2 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
    04.Nov,22
    Brian Young
    Consistent High-Quality Results
    This antibody has proven to be consistent and dependable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for TRAIL-R2 have been particularly beneficial.
    28.Jun,21

    Cite This Product

    To accurately reference this product in your publication, please use the following citation information:

    (Creative Biolabs Cat# TAB-195, RRID: AB_3111865)

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    For Research Use Only. Not For Clinical Use.

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